A subdomain in the transmembrane domain is necessary for p185neu* activation.

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

The neu Gene: an erb B-Homologous Gene Distinct from and Unlinked to the Gene Encoding the EGF Receptor

1985 • 513 citations

Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation

1987 • 508 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1986 • 341 citations

Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

1989 • 337 citations

Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion.

1988 • 321 citations

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

1990 • 266 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

1988 • 227 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains

1985 • 202 citations

A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region.

1987 • 199 citations

Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.

1988 • 186 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Inhibition of PDGF β Receptor Signal Transduction by Coexpression of a Truncated Receptor

1991 • 173 citations

A sequence motif in the transmembrane region of growth factor receptors with tyrosine kinase activity mediates dimerization

1990 • 146 citations

Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response.

1991 • 143 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

A subunit common to an IgG Fc receptor and the T-cell receptor mediates assembly through different interactions.

1991 • 141 citations

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.

1990 • 132 citations

Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

1988 • 130 citations

Human c-ros-1 Gene Homologous to the v-ros Sequence of UR2 Sarcoma Virus Encodes for a Transmembrane Receptorlike Molecule

1986 • 119 citations

Characterization of an activated human ros gene.

1986 • 115 citations

Structural requirements for the transmembrane activation of the insulin receptor kinase.

1986 • 93 citations

Linkage of tyrosine kinase activity with transforming ability of the p185neu oncoprotein.

1989 • 89 citations

Ligand-induced stimulation of epidermal growth factor receptor mutants with altered transmembrane regions.

1988 • 81 citations

Structural analysis of the transmembrane domain of the epidermal growth factor receptor.

1991 • 80 citations

p185, a Product of the neu Proto-Oncogene, Is a Receptorlike Protein Associated with Tyrosine Kinase Activity

1986 • 79 citations

Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p185 protein with its function.

1990 • 56 citations

Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha

1988 • 50 citations

Comparison of EGF receptor sequences as a guide to study the ligand binding site.

1991 • 46 citations

Activation of transforming potential of the human insulin receptor gene.

1987 • 46 citations

Characterization of an Activated Human ros Gene

1986 • 41 citations

Enhancement of tyrosine kinase activity of the Drosophila epidermal growth factor receptor homolog by alterations of the transmembrane domain

1990 • 29 citations

Membrane-anchored forms of EGF stimulate focus formation and intercellular communication.

1991 • 29 citations

Conformational changes induced by the transforming amino acid substitution in the transmembrane domain of theneu oncogene-encoded p185 protein

1989 • 22 citations

TPA inhibits the tyrosine kinase activity of the neu protein in vivo and in vitro.

1991 • 21 citations