HER2 Testing: Laboratory, Technical and Clinical Considerations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.

1997 • 811 citations

Tumor Marker Utility Grading System: a Framework to Evaluate Clinical Utility of Tumor Markers

1996 • 749 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

erbB-2 and Response to Doxorubicin in Patients With Axillary Lymph Node-Positive, Hormone Receptor- Negative Breast Cancer

1998 • 667 citations

erbB-2, p53, and Efficacy of Adjuvant Therapy in Lymph Node-Positive Breast Cancer

1998 • 628 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

1992 • 542 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

Specificity of HercepTest in Determining HER-2/neu Status of Breast Cancers Using the United States Food and Drug Administration–Approved Scoring System

1999 • 468 citations

c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases.

1996 • 423 citations

Prognostic and predictive value of c-erbB-2 overexpression in primary breast cancer, alone and in combination with other prognostic markers.

1998 • 336 citations

Elevated serum c-erbB-2 antigen levels and decreased response to hormone therapy of breast cancer.

1995 • 312 citations

Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry for the Evaluation of HER-2/neu in Breast Cancer

1999 • 310 citations

HER-2/neu (c-erb-B2) gene and protein in breast cancer.

1999 • 285 citations

ErbB-1 and ErbB-2 Acquire Distinct Signaling Properties Dependent upon Their Dimerization Partner

1998 • 259 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

Prognosis and Breast Cancer

1991 • 188 citations

Activation (Tyrosine Phosphorylation) of ErbB-2 (HER-2/neu): A Study of Incidence and Correlation With Outcome in Breast Cancer

2000 • 175 citations

The extracellular domain of the c-erbB-2 oncoprotein is released from tumor cells by proteolytic cleavage.

1993 • 156 citations

Predictive value of topoisomerase IIα and other prognostic factors for epirubicin chemotherapy in advanced breast cancer

1998 • 142 citations

Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.

1995 • 140 citations

Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.

1996 • 120 citations

Analysis of gene amplification in archival tissue by differential polymerase chain reaction.

1992 • 87 citations

Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor.

1995 • 85 citations

c-erbB-2 over-expression in amplified and non-amplified breast carcinoma samples

1999 • 58 citations

HER-2/neu gene amplification by fluorescence in situ hybridization allows risk-group assessment in node-negative breast cancer.

1999 • 43 citations

Amplification units and translocation at chromosome 17q and c- erb B-2 overexpression in the pathogenesis of breast cancer

1997 • 40 citations

Should HER2 status be routinely measured for all breast cancer patients?

1999 • 35 citations

Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience

1999 • 22 citations

Quantification of C-ERB-B2 gene amplification in breast cancer cells using fluorescence in situ hybridization and digital image analysis

1996 • 21 citations

Experts Debate Value Of HER2 Testing Methods

2000 • 19 citations

Another ingredient added to HER2 mix.

1999 • 1 citations