FUNCTIONAL ASSESSMENT OF MULTIPLE P-GLYCOPROTEIN (P-GP) PROBE SUBSTRATES: INFLUENCE OF CELL LINE AND MODULATOR CONCENTRATION ON P-GP ACTIVITY

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

2004 • 900 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

2001 • 686 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Rational use of in vitro P-glycoprotein assays in drug discovery.

2001 • 637 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

2003 • 578 citations

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1999 • 457 citations

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

1997 • 450 citations

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

2001 • 438 citations

Increased drug delivery to the brain by P-glycoprotein inhibition

2000 • 422 citations

Communication between Multiple Drug Binding Sites on P-glycoprotein

2000 • 415 citations

Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.

2000 • 384 citations

Drugs as P-glycoprotein substrates, inhibitors, and inducers

2002 • 364 citations

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1997 • 326 citations

Stimulation of P‐glycoprotein‐mediated drug transport by prazosin and progesterone

1999 • 299 citations

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

1999 • 292 citations

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: A new type of drug/drug interaction

2000 • 281 citations

P-Glycoprotein (P-gp) Mediated Efflux in Caco-2 Cell Monolayers: The Influence of Culturing Conditions and Drug Exposure on P-gp Expression Levels

1998 • 221 citations

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

2002 • 213 citations

Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein Inhibitors and Substrates

2002 • 186 citations

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

2002 • 176 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein

2002 • 166 citations

Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity.

1997 • 161 citations

Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man

2002 • 158 citations

Evidence for a Polarized Efflux System for Peptides in the Apical Membrane of Caco-2 Cells

1993 • 141 citations

Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells

2004 • 140 citations

Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein

2002 • 137 citations

Age-dependent expression of P-glycoprotein gp170 in Caco-2 cell monolayers.

1996 • 119 citations

Evidence for different ABC-transporters in Caco-2 cells modulating drug uptake.

1999 • 117 citations

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil*

1999 • 95 citations

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

2001 • 94 citations

A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.

2001 • 79 citations

Reduced gastrointestinal toxicity following inhibition of the biliary excretion of irinotecan and its metabolites by probenecid in rats.

2002 • 68 citations

Role of P-Glycoprotein as a Secretory Mechanism in Quinidine Absorption from Rat Small Intestine

1998 • 63 citations

Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?

2002 • 46 citations