The regulation of 17,20 lyase activity

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

Tertiary templates for proteins

1987 • 1,485 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Molecular Biology of Steroid Hormone Synthesis*

1988 • 1,387 citations

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

The MIDAS display system

1988 • 955 citations

Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's

1993 • 876 citations

Structure and function of cytochromes P450:a comparative analysis of three crystal structures

1995 • 660 citations

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

1991 • 547 citations

Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome.

1995 • 450 citations

Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.

1987 • 449 citations

Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.

1990 • 443 citations

Cloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21

1987 • 415 citations

Using shape complementarity as an initial screen in designing ligands for a receptor binding site of known three-dimensional structure

1988 • 396 citations

Crystal structure and refinement of cytochrome P450terp at 2·3 Å resolution

1994 • 393 citations

17α-Hydroxylase/17,20-Lyase Deficiency: From Clinical Investigation to Molecular Definition*

1991 • 387 citations

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

1995 • 370 citations

On the membrane topology of vertebrate cytochrome P-450 proteins.

1988 • 362 citations

Adrenarche: A Survey of Rodents, Domestic Animals, and Primates

1978 • 324 citations

Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase).

1981 • 298 citations

Microsomal cytochrome P-450 from neonatal pig testis: two enzymic activities (17.alpha.-hydroxalase and C17,20 associated with one protein

1981 • 291 citations

Control of Adrenal Androgen Secretion*

1980 • 271 citations

Evidence for Dissociation between Adrenarche and Gonadarche: Studies in Patients with Idiopathic Precocious Puberty, Gonadal Dysgenesis, Isolated Gonadotropin Deficiency, and Constitutionally Delayed Growth and Adolescence*

1980 • 241 citations

The Role of Cytochrome b5 in the Biosynthesis of Androgens by Human P450c17

1995 • 224 citations

C21 steroid side chain cleavage enzyme from porcine adrenal microsomes. Purification and characterization of the 17 alpha-hydroxylase/C17,20-lyase cytochrome P-450.

1984 • 212 citations

Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence.

1986 • 211 citations

A three‐dimensional model of aromatase cytochrome P450

1995 • 206 citations

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal.

1993 • 202 citations

Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex

1989 • 180 citations

Role of electron transport in the regulation of the lyase activity of C21 side-chain cleavage P-450 from porcine adrenal and testicular microsomes.

1986 • 172 citations

P450BM-3 and other Inducible Bacterial P450 Cytochromes: Biochemistry and Regulation

1991 • 170 citations

ASSIGNMENT OF THE GENE FOR ADRENAL P450cl7 (STEROID 17α-HYDR0XYLASE⁄17,20 LYASE) TO HUMAN CHROMOSOME 10.

1986 • 167 citations

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.

1993 • 167 citations

Both Isoforms of the cAMP-dependent Protein Kinase Catalytic Subunit Can Activate Transcription of the Prolactin Gene

1989 • 162 citations

STEROID 17, 20‐DESMOLASE DEFICIENCY: A NEW CAUSE OF MALE PSEUDOHERMAPHRODITISM

1972 • 161 citations

Structural Characterization of Normal and Mutant Human Steroid 17α- Hydroxylase Genes: Molecular Basis of One Example of Combined 17α- Hydroxylase/17,20 Lyase Deficiency

1988 • 154 citations

Regional Mapping of Genes Encoding Human Steroidogenic Enzymes: P450scc to 15q23–q24, Adrenodoxin to 11q22; Adrenodoxin Reductase to 17q24–q25; and P450c17 to 10q24–q25

1991 • 153 citations

Marked Attenuation of Ultradian and Circadian Rhythms of Dehydroepiandrosterone in Postmenopausal Women: Evidence for a Reduced 17,20-Desmolase Enzymatic Activity*

1990 • 153 citations

P ‐450 Cytochromes: Structure and Function

1987 • 145 citations

Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam

1989 • 143 citations

Missense mutation serine106—-proline causes 17 alpha-hydroxylase deficiency

1991 • 137 citations

Cytochrome b5 stimulates purified testicular microsomal cytochrome P-450 (C21 side-chain cleavage)

1982 • 124 citations

17α-Hydroxylase/17,20-lyase defects

1995 • 103 citations

Localization of the human CYP17 gene (cytochrome P45017α) to 10q24.3 by fluorescence in situ hybridization and simultaneous chromosome banding

1992 • 98 citations

Deletion of a phenylalanine in the N-terminal region of human cytochrome P-45017α results in partial combined 17α-hydroxylase/17,20-lyase deficiency

1989 • 97 citations

ADRENOCORTICAL FUNCTION IN PUBERTY Serum ACTH, Cortisol and Dehydroepiandrosterone in Girls and Boys

1979 • 94 citations

Construction of side-chains in homology modelling

1989 • 93 citations

Purification and some properties of cytochrome P-450 specific for steroid 17α-hydroxylation and C17C20 bond cleavage from guinea pig adrenal microsomes

1982 • 92 citations

SEQUENCES OF INTEREST: Homologous Sequences in Steroidogenic Enzymes, Steroid Receptors and a Steroid Binding Protein Suggest a Consensus Steroid-Binding Sequence

1988 • 90 citations

The role of cytochrome b5 in adrenal microsomal steroidogenesis

1992 • 89 citations

Multiple catalytic properties of the purified and reconstituted cytochrome P-450 (P-450sccII) system of pig testis microsomes.

1984 • 88 citations

A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancer

1990 • 85 citations

Regulation of steroidogenesis in NCI-H295 cells: a cellular model of the human fetal adrenal

1993 • 83 citations

Identification and location of .alpha.-helices in mammalian cytochromes P450

1989 • 83 citations

Proteins from eight eukaryotic cytochrome P-450 families share a segmented region of sequence similarity.

1988 • 80 citations

Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency.

1993 • 72 citations

Regulation of the Activities of 17-Hydroxylase and 17,20-Desmolase in the Human Adrenal Cortex: Kinetic Analysis and Inhibition by Endogenous Steroids*

1986 • 64 citations

Cytochrome b5 potentiation of cytochrome P-450 catalytic activity demonstrated by a vaccinia virus-mediated in situ reconstitution system.

1990 • 64 citations

Dissociation of Hydroxylase and Lyase Activities by Site-Directed Mutagenesis of the Rat P450_17α

1991 • 64 citations

Modeling and mutagenesis of the active site of human P450c17.

1994 • 62 citations

Male Pseudohermaphroditism Consistent with 17,20-Desmolase Deficiency

1976 • 62 citations

Point mutation of Arg440 to His in cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency.

1994 • 62 citations

Two Types of Male Pseudohermaphroditism due to 17,20-Desmolase Deficiency*

1982 • 61 citations

Human Proopiomelanocortin-(79–96), a Proposed Androgen Stimulatory Hormone, Does not Affect Steroidogenesis in Cultured Human Fetal Adrenal Cells*

1991 • 60 citations

Molecular Biology of Mineralocorticoid Metabolism

1996 • 58 citations

Human Proopiomelanocortin-(79–96), a Proposed Cortical Androgen- Stimulating Hormone, Does not Affect Steroidogenesis in Cultured Human Adult Adrenal Cells*

1991 • 55 citations

Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha-hydroxylase/17-20-lyase deficiency in two French Canadian patients.

1996 • 51 citations

Molecular basis of apparent isolated 17,20-lyase deficiency: compound heterozygous mutations in the C-terminal region (Arg(496) → Cys, Gln(461) → Stop) actually cause combined 17α-hydroxylase/17,20-lyase deficiency

1992 • 48 citations

Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase

1993 • 45 citations

The molecular basis of isolated 17,20 lyase deficiency

1998 • 35 citations

Conversion from pure 17,20-desmolase- to combined 17,20-desmolase/17α-hydroxylase deficiency with age

1992 • 34 citations

The MIDAS database system

1988 • 30 citations

Modeling and mutagenesis of the active site of human P450c17

1994 • 29 citations

TESTICULAR FUNCTION IN POST PUBERTAL MALE PSEUDOHERMAPHRODITISM

1979 • 26 citations

Isolation and Characterization of Three Forms of Joining Peptide from Adult Human Pituitaries: Lack of Adrenal Androgen-Stimulating Activity*

1991 • 22 citations

Use of aromatase metabolite ratios to characterize electron transfer from NADPH-cytochrome P450 reductase

1993 • 21 citations

Point mutation of Arg440 to His in cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency

1994 • 20 citations

Mutation R96W in cytochrome P450c17 gene causes combined 17 alpha- hydroxylase/17-20-lyase deficiency in two French Canadian patients

1996 • 18 citations

Demethylation of Specific Sites in the 5′-Flanking Region of theCYP17Genes When Bovine Adrenocortical Cells Are Placed in Culture

1992 • 18 citations

Deletion of amino acids Asp487-Ser488-Phe489 in human cytochrome P450c17 causes severe 17 alpha-hydroxylase deficiency

1993 • 17 citations

THE MOLECULAR BASIS OF ISOLATED 17,20 LYASE DEFICIENCY. • 519

1996 • 3 citations