Crystal structure and refinement of cytochrome P450terp at 2·3 Å resolution

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Solvent content of protein crystals

1968 • 7,954 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

Conformation of Polypeptides and Proteins

1968 • 2,929 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

Analytical molecular surface calculation

1983 • 2,454 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

Hydrogen bonding in globular proteins

1984 • 1,760 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

Molecular Mechanisms of Oxygen Activation

1974 • 879 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

1991 • 675 citations

Reactions and significance of cytochrome P-450 enzymes

1991 • 596 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Crystal structure of substrate-free Pseudomonas putida cytochrome P-450

1986 • 545 citations

Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate

1978 • 531 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

Determination of Absolute from Relative X-Ray Intensity Data

1942 • 423 citations

Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

1990 • 315 citations

SPIN-STATE CHANGES IN CYTOCHROME P-450 _cam ON BINDING OF SPECIFIC SUBSTRATES

1970 • 266 citations

Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme.

1982 • 256 citations

Intrahelical hydrogen bonding of serine, threonine and cysteine residues within α-helices and its relevance to membrane-bound proteins

1984 • 242 citations

The distribution of phase angles for structures containing heavy atoms. II. A modification of the normal heavy-atom method for non-centrosymmetrical structures

1959 • 231 citations

Crystal structures of metyrapone- and phenylimidazole-inhibited complexes of cytochrome P-450cam

1987 • 216 citations

Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation

1991 • 212 citations

Crystal structure of the cytochrome P-450CAM active site mutant Thr252Ala

1991 • 205 citations

The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis.

1988 • 199 citations

Theoretical model for the effects of local nonpolar heme environments on the redox potentials in cytochromes

1973 • 193 citations

Stereochemistry and deuterium isotope effects in camphor hydroxylation by the cytochrome P450cam monooxygenase system

1982 • 189 citations

Topological distribution of four-alpha-helix bundles.

1989 • 189 citations

The structural basis for substrate-induced changes in redox potential and spin equilibrium in cytochrome P-450CAM

1989 • 181 citations

Crystal structure of the carbon monoxide-substrate-cytochrome P-450CAM ternary complex

1989 • 180 citations

Catalytic mechanism of cytochrome P-450: evidence for a distal charge relay

1992 • 176 citations

Crystallographic and Modeling Methods in Molecular Design

1990 • 172 citations

P450BM-3 and other Inducible Bacterial P450 Cytochromes: Biochemistry and Regulation

1991 • 170 citations

Cytochrome P450 _cam : crystallography, oxygen activation, and electron transfer ¹

1992 • 160 citations

Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam

1989 • 143 citations

Distribution of Attack on Iron or Zinc Partly Immersed in Chloride Solutions

1942 • 141 citations

Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon.

1992 • 106 citations

O: A Macromolecule Modeling Environment

1990 • 103 citations

Inhibitor-induced conformational change in cytochrome P-450CAM

1993 • 98 citations

P450 and Human Cancer

1991 • 94 citations

Pseudomonas putida cytochrome P-450. The effect of complexes of the ferric hemeprotein on the relaxation of solvent water protons

1975 • 83 citations

Crystallization and preliminary x-ray diffraction analysis of P450terp and the hemoprotein domain of P450BM-3, enzymes belonging to two distinct classes of the cytochrome P450 superfamily.

1992 • 71 citations

Formation, crystal structure, and rearrangement of a cytochrome P-450cam iron-phenyl complex

1990 • 70 citations

[2] Modeling of mammalian P450s on basis of P450cam x-ray structure

1991 • 69 citations

Optimal sampling of the rotation function

1972 • 58 citations

The effect of cytochrome P-450cam on the NMR relaxation rate of water protons.

1979 • 51 citations

Endogenous cysteine ligation in ferric and ferrous cytochrome P-450. Direct evidence from x-ray absorption spectroscopy.

1982 • 49 citations

Developments and perspectives on the role of cytochrome P450s in chemical carcinogenesis

1991 • 19 citations