The leukemic fusion gene AML1-MDS1-EVI1 suppresses CEBPA in acute myeloid leukemia by activation of Calreticulin

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1999 • 1,091 citations

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

1997 • 929 citations

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

2001 • 900 citations

Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.

1989 • 641 citations

Disruption of differentiation in human cancer: AML shows the way

2003 • 612 citations

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

2002 • 514 citations

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors

1998 • 483 citations

AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia

2001 • 463 citations

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

2002 • 428 citations

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

1988 • 417 citations

A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells

1992 • 413 citations

Biallelic and Heterozygous Point Mutations in the Runt Domain of theAML1/PEBP2B Gene Associated With Myeloblastic Leukemias

1999 • 408 citations

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony- stimulating factor receptor promoter in myeloid cells

1996 • 341 citations

BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2

2001 • 313 citations

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein α in myelodysplastic syndromes and acute myeloid leukemias

2002 • 301 citations

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

1996 • 289 citations

Chromosome translocations: dangerous liaisons revisited

2001 • 272 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors.

1988 • 203 citations

Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia

1993 • 193 citations

C/EBP Bypasses Granulocyte Colony-Stimulating Factor Signals to Rapidly Induce PU.1 Gene Expression, Stimulate Granulocytic Differentiation, and Limit Proliferation in 32D cl3 Myeloblasts

1999 • 171 citations

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression

2003 • 154 citations

Phosphorylation of C/EBPα Inhibits Granulopoiesis

2003 • 153 citations

t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy- related myelodysplastic syndrome and acute myeloid leukemia

1990 • 140 citations

t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy- related myelodysplastic syndrome and acute myeloid leukemia

1990 • 128 citations

The EVI1 gene in myeloid leukemia

1997 • 126 citations

CBFA2(AML1) Translocations With Novel Partner Chromosomes in Myeloid Leukemias: Association With Prior Therapy

1998 • 126 citations

MDS1/EVI1 enhances TGF-β1 signaling and strengthens its growth-inhibitory effect, but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-β1

1999 • 110 citations

Dual Functions of the AML1/Evi-1 Chimeric Protein in the Mechanism of Leukemogenesis in t(3;21) Leukemias

1995 • 108 citations

Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia

1987 • 95 citations

Calreticulin Interacts with C/EBPα and C/EBPβ mRNAs and Represses Translation of C/EBP Proteins

2002 • 94 citations

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: A model for human AML

2000 • 92 citations

Inhibition of CCAAT/Enhancer-binding Protein α and β Translation by Upstream Open Reading Frames

1998 • 83 citations

Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

2001 • 77 citations

Cell lineage-specific and differentiation-dependent patterns of CCAAT/enhancer binding protein alpha expression in the gut epithelium of normal and transgenic mice.

1993 • 73 citations

The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells

2002 • 62 citations

Restoration of C/EBPα Expression in a BCR-ABL+ Cell Line Induces Terminal Granulocytic Differentiation

2003 • 59 citations

Identification of a Common Ecotropic Viral Integration Site, Evi-1, in the DNA of AKXD Murine Myeloid Tumors

1988 • 51 citations

Both AML1 and EVI1 oncogenic components are required for the cooperation of AML1/MDS1/EVI1 with BCR/ABL in the induction of acute myelogenous leukemia in mice

2004 • 50 citations

Transcription Factor C/EBPα: Novel Sites of Expression and Cloning of the Human Gene

1997 • 35 citations

NF-E2p18/mafK is required in DMSO-induced differentiation of Friend erythroleukemia cells by enhancing NF-E2 activity

1997 • 30 citations

A new translocation that rearranges the AML1 gene in a patient with T-cell acute lymphoblastic leukemia

2002 • 23 citations

CBFA2(AML1) Translocations With Novel Partner Chromosomes in Myeloid Leukemias: Association With Prior Therapy

1998 • 17 citations