CBFA2(AML1) Translocations With Novel Partner Chromosomes in Myeloid Leukemias: Association With Prior Therapy

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

1996 • 1,195 citations

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.

1991 • 897 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

1995 • 566 citations

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion

1995 • 563 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 494 citations

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

1995 • 454 citations

The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation

1994 • 361 citations

AML1 and the 8;21 and 3;21 translocations in acute and chronic myeloid leukemia

1995 • 346 citations

TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

1996 • 306 citations

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

1994 • 272 citations

Alternative splicing and genomic structure of theAML1gene involved in acute myeloid leukemia

1995 • 269 citations

8;21 translocation in acute granulocytic leukaemia: cytological, cytochemical and clinical features

1984 • 248 citations

Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.

1990 • 247 citations

t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia

1994 • 229 citations

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.

1996 • 153 citations

t(3;21)(q26;q22): a recurring chromosomal abnormality in therapy- related myelodysplastic syndrome and acute myeloid leukemia

1990 • 128 citations

Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis

1993 • 116 citations

Cytogenetic characteristics of therapy‐related acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases

1987 • 109 citations

Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia

1987 • 95 citations

Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21).

1994 • 85 citations

Balanced translocations involving chromosome bands 11q23 and 21q22 in therapy-related leukemia [letter]

1992 • 83 citations

Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locus

1997 • 73 citations

Correlation between theETV6/CBFA2 (TEL/AMLI) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia

1996 • 60 citations

The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

1998 • 29 citations

Therapy-related acute leukemia associated with t(11q23) after primary acute myeloid leukemia with t(8;21): a report of two cases [letter]

1995 • 24 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 20 citations

t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia

1996 • 16 citations

Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II [letter]

1991 • 8 citations