Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

The thrifty phenotype hypothesis

2001 • 2,620 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming

2005 • 1,872 citations

Living with the Past: Evolution, Development, and Patterns of Disease

2004 • 1,804 citations

The Developmental Origins of Adult Disease

2004 • 1,678 citations

Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

1995 • 1,630 citations

The nutrition transition: worldwide obesity dynamics and their determinants

2004 • 1,519 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Recombinant Leptin for Weight Loss in Obese and Lean Adults

1999 • 1,408 citations

Fetal nutrition and adult disease

2000 • 1,332 citations

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

1997 • 1,043 citations

Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition

2000 • 1,009 citations

Socioeconomic status and obesity in adult populations of developing countries: A review

2004 • 895 citations

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

2000 • 873 citations

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

2001 • 862 citations

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

1997 • 750 citations

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

2004 • 716 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Neonatal Leptin Treatment Reverses Developmental Programming

2005 • 617 citations

Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice

2000 • 556 citations

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

2004 • 492 citations

The developmental origins of adult disease

2005 • 438 citations

A global response to a global problem : the epidemic of overnutrition.

2002 • 373 citations

Adipose tissue leptin production and plasma leptin kinetics in humans

1996 • 356 citations

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset

2004 • 264 citations

Early Nutrition and Later Adiposity

2001 • 262 citations

Detection and Quantification of the Leptin Receptor Splice Variants Ob-Ra, b, and, e in Different Mouse Tissues

1997 • 197 citations

World Health report 2002: reducing risks, promoting health life

2002 • 190 citations

Metabolic programming in animals

2001 • 182 citations

IGF-I Treatment Reduces Hyperphagia, Obesity, and Hypertension in Metabolic Disorders Induced by Fetal Programming

2001 • 143 citations

Hepatic leptin signaling in obesity

2005 • 102 citations

Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats

2002 • 99 citations

Acute changes in the response to peripheral leptin with alteration in the diet composition

2001 • 95 citations

Ageing increases SOCS-3 expression in rat hypothalamus: effects of food restriction

2002 • 89 citations

Adult growth hormone treatment reduces hypertension and obesity induced by an adverse prenatal environment

2002 • 64 citations

A role for dietary fat in leptin receptor, OB-Rb, function

2001 • 53 citations

Leptin resistance in mice is determined by gender and duration of exposure to high-fat diet

2003 • 52 citations

Chronic central administration of ghrelin reverses the effects of leptin

2004 • 49 citations

Insulin Stimulation of Hepatic Triacylglycerol Secretion in the Insulin‐Replete State

2002 • 41 citations

Leptin reduces food intake but does not alter weight regain following food deprivation in the rat

2003 • 33 citations

IGF-I Treatment Reduces Hyperphagia, Obesity, and Hypertension in Metabolic Disorders Induced by Fetal Programming

2001 • 30 citations

Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin‐deficient rats

1999 • 22 citations

Neonatal Leptin Treatment Reverses Developmental Programming

2006 • 22 citations