Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac function

The Protective Effects of Estrogen on the Cardiovascular System

1999 • 3,003 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

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Interleukin-6 Spillover in the Peripheral Circulation Increases With the Severity of Heart Failure, and the High Plasma Level of Interleukin-6 Is an Important Prognostic Predictor in Patients With Congestive Heart Failure

1998 • 556 citations

EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK

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Circulating Levels of Cytokines and Their Endogenous Modulators in Patients With Mild to Severe Congestive Heart Failure Due to Coronary Artery Disease or Hypertension

1996 • 505 citations

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

1998 • 476 citations

Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats

2002 • 294 citations

Hypoxic Stress Induces Cardiac Myocyte–Derived Interleukin-6

1995 • 291 citations

Differential regulatory effects of adenosine on cytokine release by activated human monocytes.

1994 • 287 citations

Estradiol Down‐Regulates LPS‐Induced Cytokine Production and NFkB Activation in Murine Macrophages

1997 • 285 citations

Hemodynamic Regulation of Tumor Necrosis Factor-α Gene and Protein Expression in Adult Feline Myocardium

1997 • 284 citations

Pathophysiology of Shock, Sepsis, and Organ Failure

1993 • 216 citations

Elevated plasma interleukin-6 levels in patients with acute myocardial infarction

1993 • 201 citations

Nitric oxide-mediated effects of interleukin-6 on [Ca2+]i and cell contraction in cultured chick ventricular myocytes.

1994 • 176 citations

Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.

1994 • 156 citations

Estradiol Administration After Trauma-Hemorrhage Improves Cardiovascular and Hepatocellular Functions in Male Animals

2000 • 152 citations

Interleukin-6 (IL-6) as a mediator of stunned myocardium

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JAK2/STAT3, Not ERK1/2, Mediates Interleukin-6-induced Activation of Inducible Nitric-oxide Synthase and Decrease in Contractility of Adult Ventricular Myocytes

2003 • 141 citations

The female reproductive cycle is an important variable in the response to trauma-hemorrhage

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Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock

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Estradiol Inhibits Leukocyte Adhesion and Transendothelial Migration in Rabbits In Vivo

1999 • 130 citations

Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury

1998 • 116 citations

Role of Cytokines in the Mechanism of Action of Amlodipine: The PRAISE Heart Failure Trial

1997 • 114 citations

Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males

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ROLE OF KUPFFER CELLS IN INTERLEUKIN-6 RELEASE FOLLOWING TRAUMA-HEMORRHAGE AND RESUSCITATION

1994 • 111 citations

SECRETION OF IL-6, IL-11 AND LIF BY HUMAN CARDIOMYOCYTES IN PRIMARY CULTURE

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Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture

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Testosterone: The Crucial Hormone Responsible for Depressing Myocardial Function in Males After Trauma-Hemorrhage

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INHIBITION OF NITRIC OXIDE SYNTHASE DURING HEMORRHAGIC SHOCK INCREASES HEPATIC INJURY

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Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock

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Estradiol Administration Improves Splanchnic Perfusion Following Trauma-Hemorrhage and Sepsis

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Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock

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Testosterone increases thromboxane A2 receptor density and responsiveness in rat aortas and platelets

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Sex and estrogens in protection against circulatory stress reactions

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Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage

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Mechanism of the salutary effects of 17β-estradiol following trauma-hemorrhage: direct downregulation of Kupffer cell proinflammatory cytokine production

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L-arginine restores the depressed cardiac output and regional perfusion after trauma-hemorrhage

1998 • 40 citations

Effect of Gender and Sex Steroids on the Contractile Response of Canine Coronary and Renal Blood Vessels

1996 • 40 citations

Measurement of hepatocellular function, cardiac output, effective blood volume, and oxygen saturation in rats

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Differential regulation of cardiac expression of IL-6 and TNF-α by A2- and A3-adenosine receptors

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Endotoxin, Cytokines, and Nitric Oxide in Shock

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Rat and Mouse Models of Hypovolemic-Traumatic Shock

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Much higher prevalence of carotid atheroma in a developing African country than in several Western countries

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Glucocorticoid-Induced Protection in Circulatory Shock: Role of Reticuloendothelial System Function

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Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock

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Chronic Resuscitation After Trauma-Hemorrhage and Acute Fluid Replacement Improves Hepatocellular Function and Cardiac Output

1998 • 15 citations