Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

The biology of interleukin-6

1989 • 1,964 citations

The biology of interleukin-6

1989 • 1,459 citations

Cytokine signal transduction

1994 • 1,358 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome

1993 • 1,068 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Persistent Elevation of Inflammatory Cytokines Predicts a Poor Outcome in ARDS

1995 • 747 citations

State of the Art

1983 • 655 citations

The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter.

1990 • 615 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock

1998 • 476 citations

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.

1995 • 363 citations

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability.

1989 • 342 citations

Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.

1996 • 319 citations

Acute lung injury: the role of cytokines in the elicitation of neutrophils.

1994 • 254 citations

Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin

1994 • 219 citations

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model

1993 • 208 citations

Plasma and BAL Cytokine Response to Corticosteroid Rescue Treatment in Late ARDS

1995 • 135 citations

Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells

1996 • 130 citations

Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice.

1994 • 83 citations

Interleukin-6 and its receptor in autoimmunity

1992 • 82 citations

Interleukin-6 in mouse hypersensitivity pneumonitis: changes in lung free cells following depletion of endogenous IL-6 or direct administration of IL-6

1992 • 61 citations

G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia

1998 • 59 citations

Induction of IP-10 chemokine promoter by measles virus: comparison with interferon-γ shows the use of the same response element but with differential DNA–protein binding profiles

1997 • 57 citations

Alveolar endotoxin increases alveolar liquid clearance in rats

1995 • 55 citations

Alveolar neutrophils in endotoxin-induced and bacteria-induced acute lung injury in rats

1997 • 49 citations

Hemorrhagic shock induces G-CSF expression in bronchial epithelium

1997 • 47 citations

Pro-inflammatory cytokines in lung and blood during steroid-induced Pneumocystis carinii pneumonia in rats

1996 • 27 citations

Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock

1998 • 19 citations