Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

2005 • 44,461 citations

High-Resolution Profiling of Histone Methylations in the Human Genome

2007 • 6,479 citations

A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

2006 • 5,132 citations

The Epigenomics of Cancer

2007 • 4,239 citations

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

2006 • 4,012 citations

Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis

2004 • 3,727 citations

The Role of Chromatin during Transcription

2007 • 3,396 citations

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

2002 • 1,959 citations

A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells

2007 • 1,882 citations

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells

2002 • 1,721 citations

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

2001 • 1,672 citations

Phenotypic plasticity and the epigenetics of human disease

2007 • 1,560 citations

Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

2006 • 1,430 citations

MLL translocations, histone modifications and leukaemia stem-cell development

2007 • 1,148 citations

Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark

2007 • 1,104 citations

Controlling the Elongation Phase of Transcription with P-TEFb

2006 • 1,081 citations

hDOT1L Links Histone Methylation to Leukemogenesis

2005 • 784 citations

Epigenetic gene silencing in cancer: the DNA hypermethylome

2007 • 690 citations

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

2008 • 642 citations

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

2003 • 598 citations

Breaking barriers to transcription elongation

2006 • 495 citations

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

2008 • 481 citations

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

2007 • 390 citations

Global and Hox-specific roles for the MLL1 methyltransferase

2005 • 357 citations

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

2003 • 348 citations

Modeling the Initiation and Progression of Human Acute Leukemia in Mice

2007 • 339 citations

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

2006 • 314 citations

Phenotypic characterisation of a unique non-T, non-B acute lymphoblastic leukaemia cell line

1977 • 255 citations

MLL associates specifically with a subset of transcriptionally active target genes

2005 • 221 citations

A twist for survival and cancer progression

2005 • 215 citations

Global approach to the diagnosis of leukemia using gene expression profiling

2005 • 210 citations

Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications

2005 • 182 citations

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

2001 • 181 citations

Molecular evidence for stem cell function of the slow-dividing fraction among human hematopoietic progenitor cells by genome-wide analysis

2004 • 126 citations

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin

2005 • 122 citations

The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin‐7

1994 • 115 citations

MLL fusion partners AF4 and AF9 interact at subnuclear foci

2003 • 94 citations

Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements

2003 • 91 citations

CD133‐Positive Hematopoietic Stem Cell “Stemness” Genes Contain Many Genes Mutated or Abnormally Expressed in Leukemia

2005 • 89 citations

Molecular Pathogenesis of MLL-Associated Leukemias

2005 • 51 citations

The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma

2003 • 35 citations