The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Identification of a major co-receptor for primary isolates of HIV-1

1996 • 3,649 citations

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

1996 • 3,189 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

Structure of influenza haemagglutinin at the pH of membrane fusion

1994 • 1,546 citations

Identification of the Envelope V3 Loop as the Primary Determinant of Cell Tropism in HIV-1

1991 • 871 citations

A spring-loaded mechanism for the conformational change of influenza hemagglutinin

1993 • 854 citations

Genome organization and transactivation of the human immunodeficiency virus type 2

1987 • 842 citations

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.

1991 • 598 citations

Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4

1990 • 598 citations

ASSOCIATION BETWEEN BIOLOGICAL PROPERTIES OF HUMAN IMMUNODEFICIENCY VIRUS VARIANTS AND RISK FOR AIDS AND AIDS MORTALITY

1989 • 581 citations

Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp!20 gene

1991 • 525 citations

Inhibition of Entry of HIV-1 in Neural Cell Lines by Antibodies Against Galactosyl Ceramide

1991 • 523 citations

A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition.

1992 • 482 citations

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

1990 • 461 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

The CD4 antigen: Physiological ligand and HIV receptor

1988 • 413 citations

Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor binding

1990 • 407 citations

Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells

1989 • 405 citations

Fusion mutants of the influenza virus hemagglutinin glycoprotein

1985 • 399 citations

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

1992 • 381 citations

A General Model for the Transmembrane Proteins of HIV and Other Retroviruses

1989 • 375 citations

Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture

1991 • 326 citations

CD4-independent infection of human neural cells by human immunodeficiency virus type 1

1989 • 297 citations

Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein

1991 • 295 citations

Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates

1995 • 293 citations

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo

1992 • 292 citations

Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

1992 • 287 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus

1991 • 257 citations

Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression

1994 • 253 citations

Monoclonal antibody and enzymatic profiles of human malignant T-lymphoid cells and derived cell lines.

1984 • 244 citations

Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization

1994 • 241 citations

Human immunodeficiency virus can infect CD4-negative human fibroblastoid cells.

1989 • 233 citations

Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens.

1979 • 222 citations

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.

1990 • 214 citations

Cellular Receptors and Viral Glycoproteins Involved in Retrovirus Entry

1993 • 193 citations

Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity

1992 • 192 citations

Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells

1990 • 185 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

1992 • 173 citations

Infection of brain-derived cells with the human immunodeficiency virus

1987 • 172 citations

A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion

1995 • 168 citations

Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV

1987 • 157 citations

A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism

1993 • 154 citations

Host range mutant of human immunodeficiency virus type 1: modification of cell tropism by a single point mutation at the neutralization epitope in the env gene

1991 • 154 citations

Characterization of the RNA dependent DNA polymerase of a new human T lymphotropic retrovirus (lymphadenopathy associated virus)

1984 • 151 citations

Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1

1994 • 148 citations

Truncation of the cytoplasmic domain of the simian immunodeficiency virus envelope glycoprotein increases env incorporation into particles and fusogenicity and infectivity

1993 • 145 citations

West African HIV-2-Related Human Retrovirus with Attenuated Cytopathicity

1988 • 141 citations

Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop

1993 • 134 citations

Cytoplasmic domain truncation enhances fusion activity by the exterior glycoprotein complex of human immunodeficiency virus type 2 in selected cell types

1992 • 122 citations

Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved region

1992 • 110 citations

Identification of Two Neutralizing and 8 Non-Neutralizing Epitopes on Simian Immunodeficiency Virus Envelope Using Monoclonal Antibodies

1992 • 103 citations

Structural modulations of the envelope gp120 glycoprotein of human immunodeficiency virus type 1 upon oligomerization and differential V3 loop epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor binding

1995 • 95 citations

Evidence that the structural conformation of envelope gp120 affects human immunodeficiency virus type 1 infectivity, host range, and syncytium-forming ability

1993 • 88 citations

Biological and molecular variability of human immunodeficiency virus type 2 isolates from The Gambia

1990 • 80 citations

Enhancement of Infectivity of a Non‐Syncytium Inducing HIV‐1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV‐1

1995 • 74 citations

Human immunodeficiency virus type 1 infection of SK-N-MC cells: domains of gp120 involved in entry into a CD4-negative, galactosyl ceramide/3' sulfo-galactosyl ceramide-positive cell line

1995 • 73 citations

Envelope Glycoproteins of HIV-1, HIV-2, and SIV Purified withGalanthus nivalisAgglutinin Induce Strong Immune Responses

1993 • 72 citations

HIV-2 and SIV Infection of Nonprimate Cell Lines Expressing Human CD4: Restrictions to Replication at Distinct Stages

1994 • 71 citations

An enzyme-linked immunosorbent assay for antibodies to the envelope glycoproteins of divergent strains of HIV-1

1989 • 69 citations

Back to primary school

1995 • 53 citations

CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV–1 strains in a T–cell line

1995 • 48 citations

Evidence for the Cooperation of gp120 Amino Acids 322 and 448 in SIVmac Entry

1993 • 48 citations

Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus

1994 • 44 citations

Location, exposure, and conservation of neutralizing and nonneutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein

1996 • 41 citations

Cytopathic variants of an attenuated isolate of human immunodeficiency virus type 2 exhibit increased affinity for CD4

1991 • 37 citations

Reduced glycosylation of human cell lines increases susceptibility to CD4-independent infection by human immunodeficiency virus type 2 (LAV-2/B)

1995 • 31 citations

Cellular CD44S as a determinant of human immunodeficiency virus type 1 infection and cellular tropism

1995 • 27 citations

Amino acid changes in the fourth conserved region of human immunodeficiency virus type 2 strain HIV-2ROD envelope glycoprotein modulate fusion

1993 • 19 citations

Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid)

1995 • 15 citations