Decreased ethanol preference and wheel running in Nurr1‐deficient mice

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

A psychomotor stimulant theory of addiction.

1987 • 2,704 citations

Dopamine Neuron Agenesis in Nurr1-Deficient Mice

1997 • 1,075 citations

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

1998 • 725 citations

Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

1978 • 643 citations

Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry

1992 • 588 citations

Voluntary consumption of ethanol in 15 inbred mouse strains

1993 • 564 citations

Increased Lever Pressing for Amphetamine After Pimozide in Rats: Implications for a Dopamine Theory of Reward

1975 • 536 citations

Modulation of Epidermal Growth Factor Receptor Gene Transcription by a Polymorphic Dinucleotide Repeat in Intron 1

1999 • 383 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene

1998 • 291 citations

Identifying genes for alcohol and drug sensitivity: recent progress and future directions

1999 • 259 citations

Identification of a new brain-specific transcription factor, NURR1

1992 • 229 citations

Delta FosB regulates wheel running.

2002 • 226 citations

The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions

1986 • 215 citations

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

2001 • 207 citations

Regional Brain Dopamine Metabolism: A Marker for the Speed, Direction, and Posture of Moving Animals

1985 • 191 citations

ΔFosBRegulates Wheel Running

2002 • 182 citations

Running addiction: measurement and associated psychological characteristics.

1990 • 178 citations

TECHNIQUES FOR ESTABLISHING SCHEDULES WITH WHEEL RUNNING AS REINFORCEMENT IN RATS

1993 • 177 citations

Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference

2000 • 165 citations

NURR1 Mutations in cases of schizophrenia and manic-depressive disorder

2000 • 146 citations

RUNNING AND RESPONDING REINFORCED BY THE OPPORTUNITY TO RUN: EFFECT OF REINFORCER DURATION

1997 • 143 citations

Selective Agenesis of Mesencephalic Dopaminergic Neurons in Nurr1-Deficient Mice

1999 • 140 citations

Ethanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice

1995 • 132 citations

Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen

2000 • 132 citations

The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies

2001 • 131 citations

Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson’s disease

2002 • 119 citations

Cocaine Reward and Locomotor Activity in C57BL/6J and 129/SvJ Inbred Mice and Their F1 Cross

1997 • 110 citations

Genes on mouse Chromosomes 2 and 9 determine variation in ethanol consumption

1998 • 109 citations

Identification of a Potential Nurr1 Response Element That Activates the Tyrosine Hydroxylase Gene Promoter in Cultured Cells

2000 • 107 citations

Measurement and Significance of Negative Addiction in Runners

1989 • 85 citations

The Mouse Genome Database (MGD): integration nexus for the laboratory mouse

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Negative Addiction in Male and Female Runners and Exercisers

1993 • 79 citations

4.5 kb of the rat tyrosine hydroxylase 5′ flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors

1999 • 76 citations

Running increases ethanol preference

2002 • 73 citations

Mouse Strain Differences in Oral Operant Ethanol Reinforcement under Continuous Access Conditions

1998 • 69 citations

Analysis of a Gene Encoding Two Glycine Transporter Variants Reveals Alternative Promoter Usage and a Novel Gene Structure

1998 • 64 citations

Effect of voluntary exercise on open-field behavior and on aggression in the spontaneously hypertensive rat (SHR)

1987 • 61 citations

Addiction-Prone Lewis But Not Fischer Rats Develop Compulsive Running that Coincides with Downregulation of Nerve Growth Factor Inducible-B and Neuron-Derived Orphan Receptor 1

1999 • 59 citations

Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs

1999 • 55 citations

Extracellular dopamine in the nucleus accumbens of the rat during treadmill running

1995 • 55 citations

Mutation analysis of the retinoid X receptor beta, nuclear‐related receptor 1, and peroxisome proliferator‐activated receptor alpha genes in schizophrenia and alcohol dependence: Possible haplotype association of nuclear‐related receptor 1 gene to alcohol dependence

2002 • 48 citations

Organization of the human orphan nuclear receptor Nurr1 gene

1999 • 44 citations

Organization, Sequence, Chromosomal Localization, and Promoter Identification of the Mouse Orphan Nuclear Receptor Nurr1 Gene

1997 • 38 citations

An isoform of Nurr1 functions as a negative inhibitor of the NGFI-B family signaling

1999 • 36 citations

On natural and drug-induced reward : Genetic, biochemical and behavioral comparisons

2001 • 3 citations