The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 4,142 citations

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

2002 • 3,652 citations

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

1998 • 1,408 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway

1997 • 1,207 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 • 738 citations

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids

2001 • 736 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Androstane metabolites bind to and deactivate the nuclear receptor CAR-β

1998 • 466 citations

Diverse Roles of the Nuclear Orphan Receptor CAR in Regulating Hepatic Genes in Response to Phenobarbital

2002 • 455 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

The Phenobarbital Response Enhancer Module in the Human Bilirubin Udp–Glucuronosyltransferase Ugt1a1 Gene and Regulation by the Nuclear Receptor Car

2001 • 368 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism

2001 • 356 citations

Structure and Function of Sulfotransferases

2001 • 319 citations

Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966 • 260 citations

Nuclear Orphan Receptors Control Cholesterol Catabolism

1999 • 212 citations

Organ Distribution of Multidrug Resistance Proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and Hepatic Induction of Mrp3 by Constitutive Androstane Receptor Activators in Rats

2002 • 211 citations

Identification of a Defect in the UGT1A1 Gene Promoter and Its Association with Hyperbilirubinemia

2002 • 205 citations

Nuclear receptor regulation of hepatic function

2002 • 169 citations

Activation by Diverse Xenochemicals of the 51-Base Pair Phenobarbital-Responsive Enhancer Module in theCYP2B10Gene

1998 • 160 citations

Estrogen Activation of the Nuclear Orphan Receptor CAR (Constitutive Active Receptor) in Induction of the MouseCyp2b10Gene

2000 • 155 citations

The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

2001 • 146 citations

Estrogen-Induced Cholestasis: Clues to Pathogenesis and Treatment

2007 • 119 citations

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

1998 • 99 citations

Aldehyde dehydrogenase gene superfamily: the 2000 update

2001 • 81 citations

Structural flexibility and functional versatility of mammalian P450 enzymes

1996 • 72 citations

Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

1998 • 69 citations

An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures.

1997 • 69 citations

Glucocorticoid and Sex Hormones as Activating or Modulating Factors for Expression of Cyp2b-9 and Cyp2b-L0 in the Mouse Liver and Hepatocytes

1995 • 61 citations

Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells

1991 • 51 citations

Effect of Antiepileptic Drugs on Plasma Lipoprotein (a) and Other Lipid Levels in Childhood

2001 • 41 citations

Residue Threonine 350 Confers Steroid Hormone Responsiveness to the Mouse Nuclear Orphan Receptor CAR

2002 • 22 citations