Identification of a Defect in the UGT1A1 Gene Promoter and Its Association with Hyperbilirubinemia

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

1995 • 1,424 citations

The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence

1997 • 1,140 citations

Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome

1996 • 593 citations

Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: Correlation of genotype to phenotype

2000 • 378 citations

The Phenobarbital Response Enhancer Module in the Human Bilirubin Udp–Glucuronosyltransferase Ugt1a1 Gene and Regulation by the Nuclear Receptor Car

2001 • 368 citations

Hepatic Bilirubin UDP-Glucuronyl Transferase Activity in Liver Disease and Gilbert's Syndrome

1969 • 274 citations

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

1991 • 261 citations

Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome

1995 • 196 citations

Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler–Najjar syndrome type II

1998 • 188 citations

Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase.

1994 • 171 citations

Association of Neonatal Hyperbilirubinemia With Bilirubin UDP-Glucuronosyltransferase Polymorphism

1999 • 169 citations

Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene

2000 • 168 citations

Gilbert’s syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn

1999 • 148 citations

Glucuronidation of 7-Ethyl-10-hydroxycamptothecin (SN-38) by the Human UDP-Glucuronosyltransferases Encoded at the UGT1 Locus

1999 • 136 citations

Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias

1997 • 132 citations

Prolonged Unconjugated Hyperbilirubinemia Associated With Breast Milk and Mutations of the Bilirubin Uridine Diphosphate- Glucuronosyltransferase Gene

2000 • 121 citations

Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases

2000 • 98 citations

Isolation and properties of conjugated bilirubin from bile

1970 • 94 citations

A New Type of Defect in the Gene for Bilirubin Uridine 5 '-Diphosphate-Glucuronosyltransferase in a Patient with Crigler-Najjar Syndrome Type I

1994 • 75 citations

Enhancement of Heme Catabolism by Caloric Restriction in Man

1972 • 55 citations

Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease

1998 • 53 citations

Ethanol increases liver uridine-diphosphate-glucuronyltransferase

1971 • 38 citations

Effect of Low Caloric Diet on Endogenous Carbon Monoxide Production: Normal Adults and Gilbert's Syndrome

1973 • 30 citations

Hepatic bilirubin-conjugating enzymes of man in the normal state and in liver disease

1982 • 22 citations