Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions

Myofibroblasts and mechano-regulation of connective tissue remodelling

2002 • 3,938 citations

Regulation of Wound Healing by Growth Factors and Cytokines

2003 • 3,383 citations

The endothelin system in pulmonary arterial hypertension

2004 • 498 citations

Connective Tissue Growth Factor: What's in a Name?

2000 • 483 citations

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

1997 • 406 citations

Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis

2006 • 384 citations

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

1996 • 290 citations

Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice

2000 • 222 citations

Mechanisms and consequences of fibrosis in systemic sclerosis

2006 • 175 citations

Paracrine regulation of keratinocyte proliferation and differentiation

2001 • 175 citations

Myofibroblast Differentiation Is Induced in Keratinocyte-Fibroblast Co-Cultures and Is Antagonistically Regulated by Endogenous Transforming Growth Factor-β and Interleukin-1

2004 • 172 citations

Topical Application of a Peptide Inhibitor of Transforming Growth Factor-β1 Ameliorates Bleomycin-Induced Skin Fibrosis

2005 • 158 citations

Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

2006 • 156 citations

Myocardial Fibrosis in DOCA-Salt Hypertensive Rats

2001 • 153 citations

TGF-β and CTGF have overlapping and distinct fibrogenic effects on human renal cells

2002 • 146 citations

Role of endothelin in fibrosis and anti‐fibrotic potential of bosentan

2005 • 134 citations

Scleroderma—clinical and pathological advances

2004 • 130 citations

Interstitial fibrosis and growth factors.

2000 • 129 citations

Endothelin and endothelin receptor antagonists in systemic rheumatic disease

2003 • 128 citations

Connective tissue growth factor causes persistent proα2(I) collagen gene expression induced by transforming growth factor‐β in a mouse fibrosis model

2004 • 120 citations

Endothelin-1, via ET _A Receptor and Independently of Transforming Growth Factor-β, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells

2005 • 118 citations

Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of α2β1 integrin

2006 • 96 citations

Interaction of keratinocytes and fibroblasts modulates the expression of matrix metalloproteinases-2 and -9 and their inhibitors

2005 • 96 citations

Functional Cooperation Between Smad Proteins and Activator Protein-1 Regulates Transforming Growth Factor-β–Mediated Induction of Endothelin-1 Expression

2003 • 95 citations

Dissecting the roles of endothelin,TGF-β and GM-CSF on myofibroblast differentiation by keratinocytes

2004 • 81 citations

Effects of the Protein Kinase Inhibitor, Imatinib Mesylate, on Epithelial/Mesenchymal Phenotypes: Implications for Treatment of Fibrotic Diseases

2007 • 60 citations

Mutant fibrillin 1 from tight skin mice increases extracellular matrix incorporation of microfibril‐associated glycoprotein 2 and type I collagen

2004 • 55 citations

Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts

2000 • 48 citations

Cell and Molecular Regulation of Endothelin-1 Production during Hepatic Wound Healing

2003 • 46 citations

Interstitial Fibrosis and Growth Factors

2000 • 29 citations

Fibulin-2 and Fibulin-5 Alterations in Tsk Mice Associated with Disorganized Hypodermal Elastic Fibers and Skin Tethering

2004 • 27 citations

Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins

2006 • 25 citations

SKL-2841, a dual antagonist of MCP-1 and MIP-1 beta, prevents bleomycin-induced skin sclerosis in mice

2006 • 23 citations

Transforming growth factor-beta receptor requirements for the induction of the endothelin-1 gene.

2006 • 12 citations

Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: Insight into the functional role of mutant fibrillin-1

2006 • 5 citations