Enhanced Therapeutic Effect of HSV-tk+GCV Gene Therapy and Ionizing Radiation for Prostate Cancer

Improved Survival in Patients with Locally Advanced Prostate Cancer Treated with Radiotherapy and Goserelin

1997 • 1,555 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Phase III trial of androgen suppression using goserelin in unfavorable-prognosis carcinoma of the prostate treated with definitive radiotherapy: report of Radiation Therapy Oncology Group Protocol 85-31.

1997 • 620 citations

Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma: a randomized comparative trial of the radiation therapy oncology group

1995 • 498 citations

Advanced prostate cancer: The results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone

1995 • 415 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

1999 • 306 citations

Radical Radiation Therapy in the Management of Prostatic Adenocarcinoma: The Initial Prostate Specific Antigen Value as a Predictor of Treatment Outcome

1994 • 265 citations

Combination gene therapy for liver metastasis of colon carcinoma in vivo.

1995 • 222 citations

Sensitivity and reproducibility in adenoviral infectious titer determination

1997 • 193 citations

Double Suicide Gene Therapy Augments the Antitumor Activity of a Replication-Competent Lytic Adenovirus through Enhanced Cytotoxicity and Radiosensitization

2000 • 185 citations

Prostate-specific antigen and radiation therapy for clinically localized prostate cancer

1995 • 180 citations

Prostate Cancer Gene Therapy: Herpes Simplex Virus Thymidine Kinase Gene Transduction Followed by Ganciclovir in Mouse and Human Prostate Cancer Models

1996 • 156 citations

Photon versus fast neutron external beam radiotherapy in the treatment of locally advanced prostate cancer: Results of a randomized prospective trial

1994 • 152 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Adenovirus‐mediated gene therapy of experimental gliomas

1994 • 133 citations

Progression to androgen insensitivity in a novelin vitro mouse model for prostate cancer

1995 • 121 citations

Fast Neutron Radiotherapy for Locally Advanced Prostate Cancer

1993 • 107 citations

Induction of potent antitumor natural killer cell activity by herpes simplex virus-thymidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer.

1998 • 105 citations

Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.

1998 • 56 citations

Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer

1999 • 48 citations

Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.

1997 • 45 citations