Prodrug activation gene therapy and external beam irradiation in the treatment of prostate cancer

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Improved Survival in Patients with Locally Advanced Prostate Cancer Treated with Radiotherapy and Goserelin

1997 • 1,555 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Phase III trial of androgen suppression using goserelin in unfavorable-prognosis carcinoma of the prostate treated with definitive radiotherapy: report of Radiation Therapy Oncology Group Protocol 85-31.

1997 • 620 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

The effect of local control on metastatic dissemination in carcinoma of the prostate: Long-term results in patients treated with 1251 implantation

1991 • 462 citations

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.

1996 • 418 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Beneficial effect of combination hormonal therapy administered prior and following external beam radiation therapy in localized prostate cancer

1997 • 317 citations

Radical Radiation Therapy in the Management of Prostatic Adenocarcinoma: The Initial Prostate Specific Antigen Value as a Predictor of Treatment Outcome

1994 • 265 citations

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

1996 • 260 citations

Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.

1996 • 188 citations

Neoadjuvant hormonal therapy improves the therapeutic ratio in patients with bulky prostatic cancer treated with three-dimensional conformal radiation therapy

1994 • 173 citations

Prostate Cancer Gene Therapy: Herpes Simplex Virus Thymidine Kinase Gene Transduction Followed by Ganciclovir in Mouse and Human Prostate Cancer Models

1996 • 156 citations

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

1997 • 156 citations

The “Bystander Effect”: Association of U-87 Cell Death with Ganciclovir-Mediated Apoptosis of Nearby Cells and Lack of Effect in Athymic Mice

1995 • 137 citations

Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer

1997 • 128 citations

Supraadditive apoptotic response of R3327-G rat prostate tumors to androgen ablation and radiation

1997 • 125 citations

External beam radiotherapy versus radical prostatectomy for clinical stage T1-2 prostate cancer: therapeutic implications of stratification by pretreatment PSA levels and biopsy Gleason scores.

1997 • 123 citations

Progression to androgen insensitivity in a novelin vitro mouse model for prostate cancer

1995 • 121 citations

Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

1988 • 111 citations

Effect of local tumor control on distant metastasis and survival in prostatic adenocarcinoma

1987 • 108 citations

Gene Therapy for Brain Tumors

1995 • 106 citations

Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene.

1994 • 96 citations

Effects of combination endocrine treatment on normal prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma.

1994 • 79 citations

Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents

1995 • 73 citations

Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer

1999 • 63 citations

Early Prostate Cancer: The National Results of Radiation Treatment from the Patterns of Care and Radiation Therapy Oncology Group Studies With Prospects for Improvement with Conformal Radiation and Adjuvant Androgen Deprivation

1994 • 57 citations

External beam radiotherapy for stage T1/T2 prostate cancer: how does it stack up?

1998 • 56 citations

Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transduction Renders Human Thyroid Carcinoma Cell Lines Sensitive to Ganciclovir and Radiation in Vitro and in Vivo

1997 • 50 citations

Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues.

1998 • 47 citations

Preferential radiosensitization of 9L glioma cells transduced with HSV-tk gene by acyclovir.

1997 • 45 citations

Management of unfavorable locoregional prostate carcinoma with radiation and androgen ablation

1997 • 43 citations

Enhancement of radiation response of prostatic carcinoma by taxol: therapeutic potential for late-stage malignancy.

1995 • 43 citations

Morbidity and Mortality of Local Failure after Definitive Therapy for Prostate Cancer

1989 • 41 citations

Update on the treatment of prostate cancer with external beam irradiation

1998 • 34 citations

Phase II Radiation Therapy Oncology Group Study of Hormonal Cytoreduction with Flutamide and Zoladex in Locally Advanced Carcinoma of the Prostate Treated with Definitive Radiotherapy

1990 • 32 citations

Early prostate cancer

2000 • 31 citations

Retrovirus-Mediated Herpes Simplex Virus Thymidine Kinase Gene Transduction Renders Human Thyroid Carcinoma Cell Lines Sensitive to Ganciclovir and Radiation in Vitro and in Vivo

1997 • 17 citations

Enhancement of radiation effects by acyclovir

1986 • 16 citations

Platinum drug delivery and radiation for locally advanced prostate cancer

1994 • 14 citations

Phase II trial of external beam radiation with etanidazole (SR 2508) for the treatment of locally advanced prostate cancer

1994 • 12 citations