In Situ Gene Therapy for Adenocarcinoma of the Prostate: A Phase I Clinical Trial

Cancer statistics, 1998

1998 • 2,407 citations

A Preoperative Nomogram for Disease Recurrence Following Radical Prostatectomy for Prostate Cancer

1998 • 1,249 citations

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

1993 • 1,097 citations

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

1986 • 962 citations

Update on adenovirus and its vectors

2000 • 605 citations

Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transfered by Retroviral Vectors

1990 • 514 citations

Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.

1994 • 483 citations

Adenovirus-Mediated Herpes Simplex Virus Thymidine Kinase/Ganciclovir Gene Therapy in Patients with Localized Malignancy: Results of a Phase I Clinical Trial in Malignant Mesothelioma

1998 • 352 citations

Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component.

1994 • 308 citations

Salvage Radical Prostatectomy: Outcome Measured by Serum Prostate Specific Antigen Levels

1995 • 268 citations

Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro.

1996 • 260 citations

High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus.

1994 • 257 citations

Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer

1994 • 235 citations

In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.

1995 • 227 citations

Sensitivity and reproducibility in adenoviral infectious titer determination

1997 • 193 citations

Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells.

1996 • 188 citations

Immunotherapy of prostate cancer in the Dunning rat model: use of cytokine gene modified tumor vaccines.

1994 • 181 citations

Prostate Cancer Gene Therapy: Herpes Simplex Virus Thymidine Kinase Gene Transduction Followed by Ganciclovir in Mouse and Human Prostate Cancer Models

1996 • 156 citations

Latest Developments in Gene Transfer Technology: Achievements, Perspectives, and Controversies over Therapeutic Applications

2000 • 150 citations

In vivo analysis of the 'bystander effect': a cytokine cascade.

1996 • 132 citations

Adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer

1997 • 128 citations

Prognostic Significance of Prostate Specific Antigen in Endocrine Treatment for Prostatic Cancer

1990 • 124 citations

External beam radiotherapy versus radical prostatectomy for clinical stage T1-2 prostate cancer: therapeutic implications of stratification by pretreatment PSA levels and biopsy Gleason scores.

1997 • 123 citations

SUICIDE GENE THERAPY TOXICITY AFTER MULTIPLE AND REPEAT INJECTIONS IN PATIENTS WITH LOCALIZED PROSTATE CANCER

2000 • 117 citations

Phase I/II trial evaluating combined radiotherapy and in situ gene therapy with or without hormonal therapy in the treatment of prostate cancer—A preliminary report

2001 • 91 citations

A Phase I Study of Recombinant Adenovirus Vector-Mediated Intraperitoneal Delivery of Herpes Simplex Virus Thymidine Kinase (HSV-TK) Gene and Intravenous Ganciclovir for Previously Treated Ovarian and Extraovarian Cancer Patients. University of Alabama Comprehensive Cancer Center, Birmingham, AL

1997 • 66 citations

Cooperative therapeutic effects of androgen ablation and adenovirus-mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy in experimental prostate cancer

1999 • 63 citations

GENE THERAPY FOR PROSTATE CANCER: WHERE ARE WE NOW?

2000 • 62 citations

Improvements in adenoviral vector technology: overcoming barriers for gene therapy

2000 • 56 citations

Local inflammatory response and vector spread after direct intraprostatic injection of a recombinant adenovirus containing the herpes simplex virus thymidine kinase gene and ganciclovir therapy in mice.

1998 • 56 citations

Novel strategies and therapeutics for the treatment of prostate carcinoma

2000 • 52 citations

Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene.

1996 • 43 citations

INHIBITION OF CELL-PROLIFERATION BY AN ADENOVIRUS VECTOR EXPRESSING THE HUMAN WILD TYPE-P53 PROTEIN

1993 • 42 citations

Unusual Hyperechoic Appearance of Prostate Cancer on Transrectal Ultrasonography

1992 • 33 citations

Distribution of 76Br-labeled antisense oligonucleotides of different length determined ex vivo in rats

2000 • 31 citations

Regulation of apoptosis in prostatic disease

2000 • 26 citations

Prodrug/drug sensitivity gene therapy: Current status

2000 • 23 citations

Suicide Gene Therapy for Urogenital Cancer: Current Outcome and Prospects

2000 • 23 citations

Problem of Prostate Cancer

1994 • 16 citations

Recent Developments in the Virus Therapy of Cancer

2000 • 15 citations

Adenovirus‐mediated herpes simplex virus thymidine kinase gene and ganciclovir therapy leads to systemic activity against spontaneous and induced metastasis in an orthotopic mouse model of prostate cancer

1997 • 12 citations

Prostate cancer immunotherapy at the dawn of the new millennium

2000 • 11 citations

New developments in the pharmacological management of prostate cancer

2000 • 11 citations

Clinical use of posttherapy prostate-specific antigen changes in advanced prostate cancer.

1996 • 8 citations

p53 Adenoviral vector (Ad-CMV-p53) induced prostatic growth inhibition of primary cultures of human prostate and an experimental rat model

2000 • 7 citations

Mechanisms of apoptosis regulation and antiapoptotic action of oncogenic viruses

2000 • 7 citations

Treating systemic prostate cancer: emerging drug targets and therapies

2000 • 2 citations