Role of Constitutive Androstane Receptor in the In Vivo Induction of Mrp3 and CYP2B1/2 by Phenobarbital

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

2000 • 1,704 citations

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

1998 • 1,497 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor

2002 • 888 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands

2000 • 805 citations

The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the CYP2B Gene

1998 • 697 citations

The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene

1999 • 658 citations

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

2000 • 641 citations

Phenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene

1999 • 537 citations

The Zucker-fatty rat: a review.

1977 • 514 citations

The Xenobiotic Compound 1,4-Bis[2-(3,5-Dichloropyridyloxy)]Benzene Is an Agonist Ligand for the Nuclear Receptor CAR

2000 • 407 citations

The Phenobarbital Response Enhancer Module in the Human Bilirubin Udp–Glucuronosyltransferase Ugt1a1 Gene and Regulation by the Nuclear Receptor Car

2001 • 368 citations

Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors

2001 • 357 citations

ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)

2000 • 333 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 260 citations

Characterization of inducible nature of MRP3 in rat liver

2000 • 255 citations

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)¹

1998 • 214 citations

Immunologic distribution of an organic anion transport protein in rat liver and kidney

1996 • 182 citations

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1995 • 156 citations

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers

1998 • 140 citations

Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene

1997 • 139 citations

Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats.

2000 • 117 citations

Nuclear Receptor CAR as a Regulatory Factor for the Sexually Dimorphic Induction ofCYP2B1Gene by Phenobarbital in Rat Livers

2001 • 83 citations

Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance

2001 • 80 citations

Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia.

1995 • 75 citations

Induction of hepatic mrp2 ( cmrp / cmoat ) gene expression in nonhuman primates treated with rifampicin or tamoxifen

1998 • 71 citations

Transcriptional Control of Hepatocanalicular Transporter Gene Expression

2000 • 57 citations

A Nuclear Factor (NF2d9) That Binds to the Male-Specific P450 (Cyp 2d-9) Gene in Mouse Liver

1995 • 55 citations

Characterization of the mechanisms involved in the gender differences in hepatic taurocholate uptake

1999 • 48 citations

Human MRP3 transporter: identification of the 5′-flanking region, genomic organization and alternative splice variants1The GenBank accession numbers of MRP3 and its splice variants MRP3A and MRP3B described in this paper are AF085690, AF085691 and AF085692, respectively.1

1999 • 42 citations

The Induction of Five Rat Hepatic P450 Cytochromes by Phenobarbital and Similarly Acting Compounds Is Regulated by a Sexually Dimorphic, Dietary-Dependent Endocrine Factor That Is Highly Strain Specific

1994 • 41 citations

Characterization of 5′-Flanking Region of Human MRP3

2000 • 39 citations

Cytochrome P450 2B Enzyme (CYP2B) Induction Defect Following Phenobarbital Treatment in the fa/fa Zucker Rat: Molecular Characterization

1993 • 24 citations

Mechanism of induction of rat hepatic CYP2B and 3A by the pesticide methoxychlor

1998 • 23 citations

Phenobarbital in the genetically obese Zucker rat. I. Pharmacokinetics after acute and chronic administration.

1984 • 19 citations

Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment.

1992 • 18 citations

Characterization of nuclear protein binding (AP-1, GR, and STAT) in the genetically obese (fa/fa) Zucker rat

1998 • 4 citations