A Selective Role for the TNF p55 Receptor in Autocrine Signaling following IFN-γ Stimulation in Experimental Autoimmune Uveoretinitis

Alternative activation of macrophages

2003 • 5,952 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 • 2,520 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Pattern Recognition Receptors

2002 • 1,139 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4+ T Cells Correlates with Th1/Th2 Phenotype

1998 • 640 citations

Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation

1998 • 594 citations

Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level

2001 • 334 citations

Aqueous Humor and Serum Tumor Necrosis Factor-α in Clinical Uveitis

2001 • 288 citations

Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

2001 • 247 citations

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

1999 • 201 citations

The role of tumour necrosis factor (TNF-α) in experimental autoimmune uveoretinitis (EAU)

2004 • 185 citations

Initial Cytokine Exposure Determines Function of Macrophages and Renders Them Unresponsive to Other Cytokines

1998 • 178 citations

Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75.

1995 • 163 citations

Divergent Roles for p55 and p75 Tumor Necrosis Factor Receptors in the Pathogenesis of MOG35-55-Induced Experimental Autoimmune Encephalomyelitis

2000 • 157 citations

Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication.

1996 • 151 citations

Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

1994 • 147 citations

Inhibition of tumor necrosis factor activity minimizes target organ damage in experimental autoimmune uveoretinitis despite quantitatively normal activated T cell traffic to the retina

1996 • 145 citations

TH1 AND TH2 RESPONSES IN PATHOGENESIS AND REGULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS

2002 • 133 citations

Molecular regulation of CD40 gene expression in macrophages and microglia

2003 • 119 citations

Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype.

2000 • 117 citations

Neutralizing TNF-alpha Activity Modulates T-cell Phenotype and Function in Experimental Autoimmune Uveoretinitis

1998 • 115 citations

Critical Role of Tumor Necrosis Factor-α and NF-κB in Interferon-γ-induced CD40 Expression in Microglia/Macrophages

2002 • 115 citations

Marrow-derived activated macrophages are required during the effector phase of experimental autoimmune uveoretinitis in rats

1998 • 106 citations

Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma-dependent mechanism.

1997 • 98 citations

TNF receptor 1-dependent beta cell toxicity as an effector pathway in autoimmune diabetes.

1999 • 96 citations

Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis.

2002 • 95 citations

Post-transcriptional inhibition of CD40 gene expression in microglia by transforming growth factor-β

1998 • 94 citations

Nitrosative Capacity of Macrophages Is Dependent on Nitric-oxide Synthase Induction Signals

2000 • 93 citations

Nitric Oxide Mediates Apoptosis Through Formation of Peroxynitrite and Fas/Fas-Ligand Interactions in Experimental Autoimmune Uveitis

2002 • 89 citations

Neutralizing Tumor Necrosis Factor-α Activity Suppresses Activation of Infiltrating Macrophages in Experimental Autoimmune Uveoretinitis

2003 • 86 citations

Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune uveoretinitis

1993 • 80 citations

TNF Receptor 1-Dependent β Cell Toxicity as an Effector Pathway in Autoimmune Diabetes

1999 • 77 citations

Immunomodulation of experimental autoimmune uveoretinitis: A model of tolerance induction with retinal antigens

1994 • 73 citations

Suppressor of Cytokine Signaling 1 Inhibits Cytokine Induction of CD40 Expression in Macrophages

2002 • 62 citations

Neutralizing Tumor Necrosis Factor Activity Leads to Remission in PatientsWith Refractory Noninfectious Posterior Uveitis

2004 • 61 citations

Anti-TNFα Therapy Modulates the Phenotype of Peripheral Blood CD4⁺T Cells in Patients with Posterior Segment Intraocular Inflammation

2003 • 57 citations

Interphotoreceptor Retinoid Binding Protein Peptide-induced Uveitis in B10.RIII Mice: Characterization of Disease Parameters and Immunomodulation

2001 • 27 citations