TH1 AND TH2 RESPONSES IN PATHOGENESIS AND REGULATION OF EXPERIMENTAL AUTOIMMUNE UVEORETINITIS

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

2000 • 805 citations

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial

2000 • 506 citations

Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye.

1989 • 481 citations

Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice.

1997 • 465 citations

Myelin Basic Protein–specific T Helper 2 (Th2) Cells Cause Experimental Autoimmune Encephalomyelitis in Immunodeficient Hosts Rather than Protect Them from the Disease

1997 • 433 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

Failure to Suppress the Expansion of the Activated Cd4 T Cell Population in Interferon γ–Deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis

2000 • 424 citations

Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level

2001 • 334 citations

Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen,Toxoplasma gondii

2000 • 296 citations

Chapter 3 Retinal specific antigens and immunopathogenic processes they provoke

1986 • 289 citations

The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases

2000 • 276 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

Anti–interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice

1999 • 268 citations

Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator?

1998 • 262 citations

IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.

1997 • 211 citations

Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis

1999 • 210 citations

The Th1/Th2 balance in autoimmunity

1995 • 198 citations

Crossregulation Between Th1 and Th2 Cells

1998 • 196 citations

The role of antigen and IL-12 in sustaining Th1 memory cellsin vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

2000 • 193 citations

TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1‐dependent autoimmune disease

1993 • 182 citations

Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice.

1994 • 156 citations

Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon‐γ

1996 • 141 citations

Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a T helper-1-like or a T helper-2-like response.

1997 • 133 citations

IL-10 has a protective role in experimental autoimmune uveoretinitis

1998 • 131 citations

Genetic susceptibility to experimental autoimmune uveoretinitis in the rat is associated with an elevated Th1 response.

1996 • 129 citations

Endogenous IL-12 Is Required for Induction and Expression of Experimental Autoimmune Uveitis

1998 • 110 citations

The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment.

1999 • 99 citations

Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma-dependent mechanism.

1997 • 98 citations

Uveitogenicity Is Associated with a Th1-like Lymphokine Profile: Cytokine-Dependent Modulation of Early and Committed Effector T Cells in Experimental Autoimmune Uveitis

1997 • 95 citations

T cell mechanisms in experimental autoimmune uveoretinitis: Susceptibility is a function of the cytokine response profile

1997 • 78 citations

IL-12 in Autoimmunity

1998 • 75 citations

Autoimmunity in the eye and its regulation

1994 • 74 citations

EXPERIMENTAL AUTOIMMUNE UVEITIDES: MULTIPLE ANTIGENS, DIVERSE DISEASES

2002 • 71 citations

Manipulation of the Th1/Th2 Cell Balance: An Approach to Treat Human Autoimmune Diseases?

1996 • 63 citations

Non‐Th2 Regulatory T‐Cell Control of Th1 Autoimmunity

2001 • 49 citations

GENETIC CONTROL OF SUSCEPTIBILITY IN CLINICAL AND EXPERIMENTAL UVEITIS

2002 • 32 citations

When engineered to produce latent TGF-β1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes

2000 • 32 citations

Experimental Autoimmune Uveoretinitis—Rat and Mouse

1994 • 24 citations

CENTRAL TOLERANCE MECHANISMS IN CONTROL OF SUSCEPTIBILITY TO AUTOIMMUNE UVEITIC DISEASE

2002 • 18 citations

Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis.

1999 • 10 citations

Prevention of experimental autoimmune uveoretinitis and experimental autoimmune pinealitis in (Lewis x Brown-Norway) F1 rats by HgCl2 injections.

1991 • 9 citations