Respiratory epithelial cells require Toll-like receptor 4 for induction of Human β-defensin 2 by Lipopolysaccharide
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References (51)
Pathogenic Escherichia coli
2004 • 4,914 citations
Defensins: antimicrobial peptides of innate immunity
2003 • 2,903 citations
TLR signaling pathways
2004 • 2,359 citations
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
1999 • 1,760 citations
Establishment of infection: lessons from a versatile opportunist
2000 • 1,289 citations
Signal transduction through NF-κB
1998 • 1,103 citations
The monocyte differentiation antigen, CD14, is anchored to the cell membrane by a phosphatidylinositol linkage.
1988 • 654 citations
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
1999 • 639 citations
Structure and function of lipopolysaccharides
2002 • 617 citations
Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging
2002 • 609 citations
Production of β-defensins by human airway epithelia
1998 • 574 citations
Bacterial Infection in Chronic Obstructive Pulmonary Disease in 2000: a State-of-the-Art Review
2001 • 572 citations
Innate immunity in the lung: how epithelial cells fight against respiratory pathogens
2004 • 556 citations
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
2000 • 484 citations
Discovery of five conserved β-defensin gene clusters using a computational search strategy
2002 • 480 citations
MucoidPseudomonas aeruginosa, TNF- α , and IL-1 β , but Not IL-6, Induce Human β -Defensin-2 in Respiratory Epithelia
2000 • 409 citations
Bacterial Endotoxin Is an Active Component of Cigarette Smoke
1999 • 384 citations
Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways
2004 • 352 citations
β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells
2004 • 348 citations
TIR domain-containing adaptors define the specificity of TLR signaling
2003 • 345 citations
THE EPIDEMIOLOGY OF ACUTE RESPIRATORY INFECTIONS IN CHILDREN AND ADULTS: A GLOBAL PERSPECTIVE
1990 • 313 citations
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium
2000 • 309 citations
MD-2 Binds to Bacterial Lipopolysaccharide
2001 • 308 citations
Respiratory Syncytial Virus Up-regulates TLR4 and Sensitizes Airway Epithelial Cells to Endotoxin
2003 • 279 citations
Activation of Toll-Like Receptor 2 on Human Tracheobronchial Epithelial Cells Induces the Antimicrobial Peptide Human β Defensin-2
2003 • 278 citations
Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.
1996 • 277 citations
Cutting Edge: Naturally Occurring Soluble Form of Mouse Toll-Like Receptor 4 Inhibits Lipopolysaccharide Signaling
2000 • 267 citations
Toll-Like Receptors in Normal and Cystic Fibrosis Airway Epithelial Cells
2003 • 262 citations
Current status of defensins and their role in innate and adaptive immunity
2002 • 241 citations
Neutrophil elastase up‐regulates interleukin‐8 via toll‐like receptor 4
2003 • 236 citations
Antimicrobial polypeptides in host defense of the respiratory tract
2002 • 213 citations
Antimicrobial polypeptides in host defense of the respiratory tract
2002 • 174 citations
Modulation of Human β-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production
2003 • 172 citations
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2
2004 • 162 citations
Lipopolysaccharide-binding protein and soluble CD14 transfer lipopolysaccharide to phospholipid bilayers: preferential interaction with particular classes of lipid.
1997 • 145 citations
Pulmonary Outcome in Cystic Fibrosis Is Influenced Primarily by Mucoid Pseudomonas aeruginosa Infection and Immune Status and Only Modestly by Genotype
1999 • 144 citations
Differences in LPS‐Induced Activation of Bronchial Epithelial Cells (BEAS‐2B) and Type II‐Like Pneumocytes (A‐549)
2002 • 127 citations
NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation.
2002 • 121 citations
Structural characterization of the lipid A component of Pseudomonas aeruginosa wild‐type and rough mutant lipopolysaccharides
1991 • 117 citations
Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness
2003 • 104 citations
NF-κB-mediated transcriptional regulation of human β-defensin-2 gene following lipopolysaccharide stimulation
2002 • 101 citations
Adenovirus E1A upregulates interleukin-8 expression induced by endotoxin in pulmonary epithelial cells
1997 • 78 citations
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors
2003 • 74 citations
The potential of various lipopolysaccharides to release IL-8 and G-CSF
2000 • 74 citations
Virulence Factors from Pseudomonas aeruginosa Increase Lung Epithelial Permeability
2000 • 72 citations
Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages
1998 • 52 citations
Stimulant-Dependent Modulation of Cytokines and Chemokines by Airway Epithelial Cells: Cross Talk between Pulmonary Epithelial and Peripheral Blood Mononuclear Cells
2002 • 49 citations
Intercellular Adhesion Molecule-1 Mediates Cellular Cross-Talk between Parenchymal and Immune Cells after Lipopolysaccharide Neutralization
2004 • 33 citations
Neutrophil elastase up‐regulates human β‐defensin‐2 expression in human bronchial epithelial cells
2003 • 26 citations
Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors
2003 • 24 citations
Tumor Necrosis Factor–α–Converting Enzyme: Its Role in Community‐Acquired Pneumonia
2002 • 22 citations