Evidence for a Defect in Growth Hormone-Releasing Factor Signal Transduction in the Dwarf (dw/dw) Rat Pituitary*

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1

1990 • 1,211 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.

1981 • 735 citations

Mechanism of adenylate cyclase activation by cholera toxin: Inhibition of GTP hydrolysis at the regulatory site

1977 • 726 citations

RADIOIMMUNOASSAY FOR THE MEASUREMENT OF ADENOSINE 3′,5′-CYCLIC PHOSPHATE

1969 • 600 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Growth Hormone-Releasing Hormone*

1986 • 427 citations

Human cDNA clones for four species of G alpha s signal transduction protein.

1986 • 370 citations

Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro.

1986 • 329 citations

Transcriptional regulation of growth hormone gene expression by growth hormone-releasing factor

1983 • 305 citations

Growth Hormone and Insulin Levels in Weanling Rats with Ventromedial Hypothalamic Lesions

1968 • 294 citations

Independent effects of growth hormone releasing factor on growth hormone release and gene transcription

1985 • 286 citations

Stimulation of Adenosine 3′,5′-Monophosphate Production by Growth Hormone-Releasing Factor and Its Inhibition by Somatostatin in Anterior Pituitary Cellsin Vitro*

1983 • 244 citations

Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6

1976 • 241 citations

Growth hormone-deficient dwarfism in the rat: a new mutation

1988 • 239 citations

A mutation that prevents GTP-dependent activation of the α chain of Gs

1988 • 176 citations

Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.

1977 • 173 citations

Etiology of Growth Hormone Deficiency in Little, Ames, and Snell Dwarf Mice^*

1983 • 155 citations

The G-Protein Family and Their Interaction with Receptors*

1989 • 149 citations

Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.

1988 • 145 citations

Feedback Regulation of Growth Hormone (GH)-Releasing Hormone Gene Expression by GH in Rat Hypothalamus

1988 • 142 citations

Receptor-Associated Resistance to Growth Hormone-Releasing Factor in Dwarf "Little" Mice

1986 • 133 citations

Growth Responses in a Mutant Dwarf Rat to Human Growth Hormone and Recombinant Human Insulin-Like Growth Factor I

1989 • 123 citations

Molecular Mechanism of Growth Hormone (GH) Deficiency in the Spontaneous Dwarf Rat: Detection of Abnormal Splicing of GH Messenger Ribonucleic Acid by the Polymerase Chain Reaction*

1990 • 104 citations

Decreased hypothalamic growth hormone-releasing hormone content and pituitary responsiveness in hypothyroidism.

1986 • 103 citations

Desensitization to Growth Hormone-Releasing Factor (GRF) Is Associated with Down-Regulation of GRF-Binding Sites*

1986 • 100 citations

An in vitro model for studies of intercellular communication in cultured rat anterior pituitary cells

1984 • 98 citations

Cloning and Characterization of Mouse Growth Hormone-Releasing Hormone (GRH) Complementary DNA: Increased GRH Messenger RNA Levels in the Growth Hormone-Deficient lit/lit Mouse

1989 • 98 citations

Human Pancreatic Tumor Growth Hormone (GH)-Releasing Factor and Cyclic Adenosine 3′,5′-Monophosphate Evoke GH Release from Anterior Pituitary Cells: The Effects of Pertussis Toxin, Cholera Toxin, Forskolin, and Cycloheximide^*

1984 • 79 citations

Growth Hormone-Releasing Factor Induces c-fosExpression in Cultured Primary Pituitary Cells*

1987 • 77 citations

Increase in Gs and cyclic AMP generation in HIT cells

1989 • 72 citations

Tumor promoters enhance basal and growth hormone releasing factor stimulated cyclic AMP levels in anterior pituitary cells

1985 • 67 citations

Prostaglandins E1 and E2 interact with prostaglandin F2alpha to regulate initiation of DNA replication and cell division in swiss 3T3 cells.

1982 • 63 citations

Protein kinase C enhances growth hormone releasing factor (1-40)-stimulated cyclic AMP levels in anterior pituitary. Actions of somatostatin and pertussis toxin.

1986 • 59 citations

Protein kinase C stimulates adenylate cyclase activity in prolactin‐secreting rat adenoma (GH₄C₁) pituicytes by inactivating the inhibitory GTP‐binding protein G_i

1989 • 47 citations

Specific binding of synthetic human pancreatic growth hormone releasing factor (1–40-OH) to bovine anterior pituitaries

1985 • 45 citations

Interactions between growth hormone-releasing factor, prostaglandin E2 and somatostatin on cyclic AMP accumulation in rat adenohypophysial cells in culture

1983 • 43 citations

Regulation of Growth Hormone mRNA and Pro-Opiomelanocortin mRNA Levels by Cyclic AMP in Rat Anterior Pituitary Cells in Culture

1986 • 34 citations

Effects of Thyroid Hormone Deficiency and Replacement on Rat Hypothalamic Growth Hormone (GH)-Releasing Hormone Gene Expressionin VivoAre Mediated by GH

1990 • 33 citations

Cyclic adenosine nucleotides and growth hormone-releasing factor increase cytosolic growth hormone messenger RNA levels in cultured rat pituitary cells

1986 • 20 citations

A Cellular Basis for Growth Hormone Deficiency in the Dwarf Rat: Analysis of Growth Hormone and Prolactin Release by Reverse Hemolytic Plaque Assay*

1989 • 19 citations