Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
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References (73)
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 • 2,024 citations
A role for glucagon-like peptide-1 in the central regulation of feeding
1996 • 1,880 citations
DETERMINATION OF BLOOD SUGAR
1945 • 1,816 citations
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
1999 • 1,467 citations
A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance
1998 • 1,173 citations
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.
1992 • 880 citations
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
1999 • 862 citations
Hypothalamic insulin signaling is required for inhibition of glucose production
2002 • 852 citations
The incretin concept today
1979 • 730 citations
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
1996 • 728 citations
Acute stimulation of glucose metabolism in mice by leptin treatment
1997 • 717 citations
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
2001 • 647 citations
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
2004 • 613 citations
Glucose and Osmosensitive Neurones of the Rat Hypothalamus
1969 • 588 citations
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
1996 • 581 citations
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
2002 • 472 citations
Distribution of GLP‐1 Binding Sites in the Rat Brain: Evidence that Exendin‐4 is a Ligand of Brain GLP‐1 Binding Sites
1995 • 451 citations
Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression
2004 • 429 citations
Central melanocortin receptors regulate insulin action
2001 • 335 citations
Distribution of glucagonlike peptide I (GLP‐I), glucagon, and glicentin in the rat brain: An immunocytochemical study
1988 • 325 citations
Central melanocortin receptors regulate insulin action
2001 • 317 citations
Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet
2002 • 280 citations
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
1998 • 279 citations
The expression of GLP‐1 receptor mRNA and protein allows the effect of GLP‐1 on glucose metabolism in the human hypothalamus and brainstem
2005 • 277 citations
Glucagonlike peptide 1: A newly discovered gastrointestinal hormone
1994 • 258 citations
Glucose Competence of the Hepatoportal Vein Sensor Requires the Presence of an Activated Glucagon-Like Peptide-1 Receptor
2001 • 247 citations
Neural network of glucose monitoring system
1984 • 230 citations
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004 • 223 citations
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004 • 214 citations
CNS Glucagon-Like Peptide-1 Receptors Mediate Endocrine and Anxiety Responses to Interoceptive and Psychogenic Stressors
2003 • 208 citations
Neuronal regulation of hepatic glucose metabolism in mammals
1987 • 185 citations
Expression of the Glucagon‐Like Peptide‐1 Receptor Gene in Rat Brain
1996 • 179 citations
Novel Glucosensor for Hypoglycemic Detection Localized to the Portal Vein
1997 • 170 citations
Glucagon-like peptide containing pathways in the regulation of feeding behaviour
2001 • 167 citations
Heterogeneous control of blood flow amongst different vascular beds
2000 • 167 citations
Identification and Localization of Glucagon-Like Peptide-1 and Its Receptor in Rat Brain*
1987 • 166 citations
Mammalian Glucokinase
1993 • 153 citations
Evidence that carotid bodies play an important role in glucoregulation in vivo.
2000 • 148 citations
Identification and Characterization of Glucoresponsive Neurons in the Enteric Nervous System
1999 • 148 citations
Portal glucose infusion in the mouse induces hypoglycemia: evidence that the hepatoportal glucose sensor stimulates glucose utilization.
2000 • 140 citations
Invited Review: Effect of acute exercise on insulin signaling and action in humans
2002 • 139 citations
Hypothalamic insulin signaling is required for inhibition of glucose production
2002 • 134 citations
Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia.
2000 • 122 citations
Regulation of glucogen metabolism in liver by the autonomic nervous system VI. Possible mechanism of phosphorylase activation by the splanchnic nerve
1975 • 115 citations
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.
1993 • 115 citations
Insulin Signaling in the Central Nervous System Is Critical for the Normal Sympathoadrenal Response to Hypoglycemia
2005 • 115 citations
Appetite and Body Weight Regulation: Is It All in the Brain?
1997 • 112 citations
The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor
2000 • 108 citations
The Effects of Hyperinsulinemia and Hyperglycemia on GLUT4 and Hexokinase II mRNA and Protein in Rat Skeletal Muscle and Adipose Tissue
1993 • 91 citations
Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region
2004 • 90 citations
Intracerebroventricular Infusion of Glucose, Insulin, and the Adenosine Monophosphate-Activated Kinase Activator, 5-Aminoimidazole-4-Carboxamide-1-β-<scp>d</scp>-Ribofuranoside, Controls Muscle Glycogen Synthesis
2004 • 76 citations
Evidence That Extrapancreatic GLUT2-Dependent Glucose Sensors Control Glucagon Secretion
2001 • 74 citations
Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem
1998 • 71 citations
Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs
2003 • 70 citations
Effect of Leptin on Hypothalamic GLP-1 Peptide and Brain-Stem Pre-proglucagon mRNA
2000 • 63 citations
Autonomic dysfunction of the beta-cell and the pathogenesis of obesity.
2003 • 60 citations
Identification of Specific Binding Sites for Glucagon-Like Peptide-1 on the Posterior Lobe of the Rat Pituitary
1995 • 60 citations
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
2003 • 59 citations
GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
2003 • 55 citations
Novel glucosensor for hypoglycemic detection localized to the portal vein
1997 • 53 citations
Changes in lateral hypothalamic neuronal activity accompanying hyper- and hypoglycemias
1988 • 53 citations
Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype
2004 • 51 citations
The Antidiabetic Agent Sodium Tungstate Activates Glycogen Synthesis through an Insulin Receptor-independent Pathway
2003 • 48 citations
Neuropeptides and Gastric Mucosal Homeostasis
2004 • 42 citations
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
2002 • 36 citations
Regulation of Energy Balance by Peptides: A Review
2005 • 35 citations
Glucagon-like peptide-1 (7–36) amide as a novel neuropeptide
1998 • 33 citations
Mechanism of glucose sensing in the small intestine
2003 • 33 citations
Local versus indirect action of glucose on the lateral hypothalamic neurons sensitive to glycemic level
1990 • 30 citations
Heterogeneous control of blood flow amongst different vascular beds
2001 • 28 citations
Mammalian Glucokinase
1993 • 16 citations
Glucagon-like peptide containing pathways in the regulation of feeding behaviour
2001 • 14 citations
The effects of hyperinsulinemia and hyperglycemia on GLUT4 and hexokinase II mRNA and protein in rat skeletal muscle and adipose tissue
1993 • 11 citations