Mouse-human immunoglobulin G1 chimeric antibodies with activities against Cryptococcus neoformans

A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

1991 • 662 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

EPIDEMIOLOGIC DIFFERENCES BETWEEN THE TWO VARIETIES OF CRYPTOCOCCUS NEOFORMANS1

1984 • 487 citations

Immunoglobulin G: Functional sites

1985 • 442 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Protective murine monoclonal antibodies to Cryptococcus neoformans

1992 • 289 citations

Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies.

1988 • 281 citations

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

1991 • 273 citations

The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages

1983 • 245 citations

Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody

1987 • 243 citations

Correlation between segmental flexibility and effector function of antibodies

1984 • 235 citations

Antibodies Elicited by a Cryptococcus neoformans-Tetanus Toxoid Conjugate Vaccine Have the Same Specificity as Those Elicited in Infection

1992 • 218 citations

Capsular Polysaccharides of Cryptococcus neoformans

1984 • 196 citations

Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis

1991 • 179 citations

THE RESULTS OF THE SERUM TREATMENT IN THIRTEEN HUNDRED CASES OF EPIDEMIC MENINGITIS

1913 • 179 citations

Human combinatorial antibody libraries to hepatitis B surface antigen.

1992 • 174 citations

Persistence of initial infection in recurrent Cryptococcus neoformans meningitis

1993 • 173 citations

Structure and antigenic activity of the capsular polysaccharide of Cryptococcus neoformans serotype A

1980 • 156 citations

Monoclonal antibody based ELISAs for cryptococcal polysaccharide

1992 • 155 citations

Serologic Tests in Diagnosis and Prognosis of Cryptococcosis

1966 • 154 citations

A galactoxylomannan antigen of Cryptococcus neoformans serotype A

1982 • 153 citations

Antimicrobial proteins of murine macrophages

1993 • 153 citations

The genetic basis of antibody production: A single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse

1983 • 151 citations

Molecular characterization of the humoral responses to Cryptococcus neoformans infection and glucuronoxylomannan-tetanus toxoid conjugate immunization.

1993 • 150 citations

Passive immunization against Cryptococcus neoformans with an isotype-switch family of monoclonal antibodies reactive with cryptococcal polysaccharide

1990 • 148 citations

Combinatorial immunoglobulin libraries on the surface of phage (Phabs): Rapid selection of antigen-specific fabs

1991 • 146 citations

Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microglia.

1992 • 144 citations

Therapeutic efficacy of monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan alone and in combination with amphotericin B

1994 • 140 citations

Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans.

1989 • 131 citations

Direct measurement of antibody affinity distribution by Haften-inhibition enzyme immunoassay

1984 • 129 citations

Complement Depletion in Cryptococcal Sepsis

1978 • 124 citations

Genetic Control of Susceptibility to Cryptococcus neoformans in Mice

1980 • 124 citations

Cryptococcosis (Torulosis)

1959 • 123 citations

The mouse antibody response to infection with Cryptococcus neoformans: VH and VL usage in polysaccharide binding antibodies.

1991 • 116 citations

Monoclonal antibodies to Cryptococcus neoformans capsular polysaccharide modify the course of intravenous infection in mice

1994 • 115 citations

Antibody-mediated protection in mice with lethal intracerebral Cryptococcus neoformans infection.

1993 • 113 citations

Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole

1993 • 109 citations

Expression in COS cells of a mouse—human chimaeric B72.3 antibody

1987 • 100 citations

Role of heavy chain constant domains in antibody-antigen interaction. Apparent specificity differences among streptococcal IgG antibodies expressing identical variable domains.

1993 • 99 citations

Improved Amphotericin B Activity by a Monoclonal Anti-Cryptococcus neoformans Antibody: Study during Murine Cryptococcosis and Mechanisms of Action

1991 • 96 citations

Effects of Antifungal Agents and Interferon on Macrophage Cytotoxicity for Fungi and Tumor Cells

1987 • 87 citations

Antibody-dependent Killing of Cryptococcus neoformans by Human Peripheral Blood Mononuclear Cells

1974 • 83 citations

Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity.

1986 • 79 citations

Antibody-dependent natural killer cell-mediated growth inhibition of Cryptococcus neoformans

1986 • 79 citations

H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate.

1991 • 79 citations

Recent advances in biology and immunology of Cryptococcus neoformans.

1992 • 79 citations

Human natural killer cells do not inhibit growth of Cryptococcus neoformans in the absence of antibody

1990 • 76 citations

Nature of the effector cells responsible for antibody-dependent cell-mediated killing of Cryptococcus neoformans

1976 • 76 citations

Pronounced enhancement of .NO-dependent antimicrobial action by an .NO-oxidizing agent, imidazolineoxyl N-oxide

1993 • 76 citations

Effects of strain variation, serotype, and structural modification on kinetics for activation and binding of C3 to Cryptococcus neoformans

1993 • 75 citations

Influence of Cryptococcal Antigens on Cell-Mediated Immunity

1988 • 68 citations

Contribution of complement component C5 to the pathogenesis of experimental murine cryptococcosis

1985 • 64 citations

Role of IgG and complement component C5 in the initial course of experimental cryptococcosis.

1989 • 63 citations

Opsonization of Cryptococcus neoformans by human immunoglobulin G: role of immunoglobulin G in phagocytosis by macrophages

1979 • 62 citations

Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization

1992 • 62 citations

Opsonization of encapsulated Cryptococcus neoformans by specific anticapsular antibody

1981 • 52 citations

Hemophilus influenzae(Pfeiffer Bacillus) Meningitis and Its Specific Treatment

1937 • 52 citations

Passive immunization in murine cryptococcosis

1981 • 50 citations

Serum Protein Enhancement of Antibiotic Therapy in Cryptococcosis

1964 • 47 citations

Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans

1991 • 43 citations

Identification of rare immunoglobulin switch variants using the ELISA spot assay

1992 • 41 citations

Genetic control of the humoral response to cryptococcal capsular polysaccharide in mice

1988 • 38 citations

Fc region-dependence of IgG3 anti-streptococcal group A carbohydrate antibody functional affinity. I. The effect of temperature.

1988 • 33 citations

Recent advances in biology and immunology ofCryptococcus neoformans

1992 • 32 citations

Macrophage-mediated fungistasis: requirement for a macromolecular component in serum.

1986 • 32 citations

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