Phe-308 and Phe-312 in Transmembrane Domain 7 Are Major Sites of α1-Adrenergic Receptor Antagonist Binding

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Identification of residues required for ligand binding to the beta-adrenergic receptor.

1987 • 398 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA.

1991 • 334 citations

Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor.

1996 • 188 citations

A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists

1991 • 146 citations

Activation of the α1b-Adrenergic Receptor Is Initiated by Disruption of an Interhelical Salt Bridge Constraint

1996 • 133 citations

Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors.

1992 • 127 citations

Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes.

1994 • 123 citations

Cloning, expression, and tissue distribution of the rat homolog of the bovine alpha 1C-adrenergic receptor provide evidence for its classification as the alpha 1A subtype.

1994 • 116 citations

The Unique Nature of the Serine Interactions for α1-Adrenergic Receptor Agonist Binding and Activation

1996 • 103 citations

Lack of cross-desensitization between structurally dissimilar α-adrenoceptor agonists

1977 • 97 citations

Identification of Critical Determinants of α1-Adrenergic Receptor Subtype Selective Agonist Binding

1995 • 92 citations

Identification of critical extracellular loop residues involved in alpha 1-adrenergic receptor subtype-selective antagonist binding.

1996 • 90 citations

Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

1990 • 76 citations

Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines

1983 • 64 citations

Recent advances in the molecular pharmacology of the α1-adrenergic receptors

1996 • 56 citations

Chimeric Receptor Analysis of the Ketanserin Binding Site in the Human 5-Hydroxytryptamine_1DReceptor: Importance of the Second Extracellular Loop and Fifth Transmembrane Domain in Antagonist Binding

1998 • 50 citations

Phe310 in Transmembrane VI of the α1B-Adrenergic Receptor Is a Key Switch Residue Involved in Activation and Catecholamine Ring Aromatic Bonding

1999 • 47 citations

Phenylalanine in the Second Membrane-Spanning Domain of α_1A-Adrenergic Receptor Determines Subtype Selectivity of Dihydropyridine Antagonists

1996 • 45 citations

The Third Extracellular Loop of the β₂-Adrenergic Receptor Can Modulate Receptor/G Protein Affinity

1998 • 39 citations

Genetic analysis of the molecular basis for β‐adrenergic receptor subtype specificity

1989 • 22 citations

Novel Aromatic Residues in Transmembrane Domains IV and V Involved in Agonist Binding at α1a-Adrenergic Receptors

2000 • 21 citations

δ-Opioid receptor: the third extracellular loop determines naltrindole selectivity

1996 • 20 citations