Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of gag precursors and result in the release of noninfectious virus particles

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Potential Metal-Binding Domains in Nucleic Acid Binding Proteins

1986 • 1,096 citations

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

1989 • 883 citations

Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

1989 • 831 citations

Assembly and release of HIV-1 precursor Pr55gag virus-like particles from recombinant baculovirus-infected insect cells

1989 • 734 citations

New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral Activity

1989 • 689 citations

Myristoylation-dependent replication and assembly of human immunodeficiency virus 1.

1990 • 634 citations

Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus

1990 • 531 citations

A Synthetic HIV-1 Protease Inhibitor with Antiviral Activity Arrests HIV-Like Particle Maturation

1990 • 382 citations

Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA

1990 • 380 citations

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

1989 • 359 citations

The HIV-1 Protease as a Therapeutic Target for AIDS

1992 • 343 citations

Standardized and simplified nomenclature for proteins common to all retroviruses

1988 • 336 citations

Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate.

1988 • 323 citations

Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence.

1988 • 312 citations

Amino acid sequence homology in gag region of reverse transcribing elements and the coat protein gene of cauliflower mosaic virus

1986 • 305 citations

Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.

1992 • 282 citations

Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein

1993 • 274 citations

Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid protein

1989 • 252 citations

The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent

1993 • 236 citations

Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS

1995 • 228 citations

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles

1993 • 228 citations

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds

1993 • 198 citations

Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.

1991 • 190 citations

Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus

1988 • 188 citations

Human immunodeficiency virus nucleocapsid protein accelerates strand transfer of the terminally redundant sequences involved in reverse transcription.

1994 • 188 citations

An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection.

1990 • 186 citations

Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle

1993 • 177 citations

Human immunodeficiency virus type 1 Gag proteins are processed in two cellular compartments.

1991 • 161 citations

A retroviral Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys peptide binds metal ions: spectroscopic studies and a proposed three-dimensional structure.

1989 • 153 citations

Primary structure of the low molecular weight nucleic acid-binding proteins of murine leukemia viruses.

1981 • 153 citations

Tightly bound zinc in human immunodeficiency virus type 1, human T-cell leukemia virus type I, and other retroviruses

1992 • 146 citations

Mutations in Rous sarcoma virus nucleocapsid protein p12 (NC): deletions of Cys-His boxes

1988 • 136 citations

Influence of Human Immunodeficiency Virus Nucleocapsid Protein on Synthesis and Strand Transfer by the Reverse Transcriptase in Vitro

1995 • 135 citations

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

1995 • 128 citations

Point mutations in the proximal Cys-His box of Rous sarcoma virus nucleocapsid protein

1990 • 123 citations

The nucleocapsid protein isolated from HIV-1 particles binds zinc and forms retroviral-type zinc fingers

1990 • 111 citations

Formation of Stable and Functional HIV-1 Nucleoprotein Complexesin Vitro

1995 • 104 citations

Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag-Pol influence PR autoprocessing

1995 • 95 citations

1H NMR structure and biological studies of the His23 .fwdarw. Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity

1994 • 93 citations

Trans-activation of the 5' to 3' viral DNA strand transfer by nucleocapsid protein during reverse transcription of HIV1 RNA.

1993 • 90 citations

Thiazolobenzimidazole: Biological and biochemical anti-retroviral activity of a new nonnucleoside reverse transcriptase inhibitor

1993 • 88 citations

The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.

1993 • 69 citations

Effect of rearrangements and duplications of the Cys-His motifs of Rous sarcoma virus nucleocapsid protein

1993 • 48 citations

Characterization of human immunodeficiency virus type 1 Pr55gag membrane association in a cell-free system: requirement for a C-terminal domain.

1994 • 42 citations

Identification and Characterization of Multiple Forms of Bovine Brain N-Myristoyltransferase

1995 • 42 citations

Phosphorylation of HIV-1 gag proteins by protein kinase C.

1993 • 38 citations

Specific Disulfide Formation in the Oxidation of HIV-1 Zinc Finger Protein Nucleocapsid p7

1995 • 32 citations

Inactivation of murine leukemia virus by compounds that react with the zinc finger in the viral nucleocapsid protein

1996 • 30 citations

Synthesis and characterization of inhibitors of myristoyl-CoA:Protein N-myristoyltransferase

1991 • 14 citations