Human immunodeficiency virus proteinase dimer as component of the viral polyprotein prevents particle assembly and viral infectivity.

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

1986 • 2,918 citations

Complete nucleotide sequence of the AIDS virus, HTLV-III

1985 • 2,236 citations

Vectors for selective expression of cloned DNAs by T7 RNA polymerase

1987 • 1,449 citations

Active human immunodeficiency virus protease is required for viral infectivity.

1988 • 1,309 citations

The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA

1989 • 1,280 citations

Conserved Folding in Retroviral Proteases: Crystal Structure of Synthetic HIV-1 Protease

1989 • 1,155 citations

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression

1988 • 936 citations

Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay

1985 • 860 citations

A structural model for the retroviral proteases

1987 • 594 citations

VIRAL PROTEINASES

1988 • 448 citations

The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region

1989 • 359 citations

Synthesis of infectious poliovirus RNA by purified T7 RNA polymerase.

1986 • 344 citations

Standardized and simplified nomenclature for proteins common to all retroviruses

1988 • 336 citations

Complete mutagenesis of the HIV-1 protease

1989 • 335 citations

T7 lysozyme inhibits transcription by T7 RNA polymerase

1987 • 266 citations

Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides.

1989 • 166 citations

Proteolytic processing of polyproteins in the replication of RNA viruses

1989 • 166 citations

Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein.

1990 • 145 citations

Processing of in vitro-synthesized gag precursor proteins of human immunodeficiency virus (HIV) type 1 by HIV proteinase generated in Escherichia coli

1988 • 110 citations

Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease.

1990 • 68 citations

Electrotransfection of human lymphoid and myelold cell lines

1988 • 23 citations