DNA Microarrays in Clinical Oncology

The Hallmarks of Cancer

2000 • 27,569 citations

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Molecular portraits of human breast tumours

2000 • 15,445 citations

The Sequence of the Human Genome

2001 • 13,500 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.

1996 • 3,063 citations

Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation

1999 • 2,990 citations

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

2001 • 2,749 citations

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

2001 • 2,626 citations

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

2001 • 2,560 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Prediction of central nervous system embryonal tumour outcome based on gene expression

2002 • 2,359 citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network

2001 • 2,058 citations

Multiclass cancer diagnosis using tumor gene expression signatures

2001 • 2,021 citations

Molecular classification of cutaneous malignant melanoma by gene expression profiling

2000 • 2,011 citations

Delineation of prognostic biomarkers in prostate cancer

2001 • 1,694 citations

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

2001 • 1,672 citations

Computational analysis of microarray data

2001 • 1,502 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

Predicting the clinical status of human breast cancer by using gene expression profiles

2001 • 1,336 citations

Diversity of gene expression in adenocarcinoma of the lung

2001 • 1,299 citations

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

2001 • 1,297 citations

Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations

2000 • 880 citations

INTERNATIONAL HUMAN GENOME SEQUENCING CONSORTIUM. INITIAL SEQUENCING AND ANALYSIS OF THE HUMAN GENOME

2001 • 790 citations

Molecular interactions on microarrays

1999 • 788 citations

Molecular classification of human carcinomas by use of gene expression signatures.

2001 • 681 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

2001 • 662 citations

Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays.

2001 • 607 citations

Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression.

2001 • 544 citations

Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease

2001 • 454 citations

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.

1998 • 444 citations

Cancer genetics

2001 • 421 citations

Gene expression profiling of clear cell renal cell carcinoma: Gene identification and prognostic classification

2001 • 408 citations

In vivo gene expression profile analysis of human breast cancer progression.

1999 • 396 citations

Biomedical Discovery with DNA Arrays

2000 • 362 citations

Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis.

2001 • 341 citations

Identification of differentially expressed genes in human gliomas by DNA microarray and tissue chip techniques.

2000 • 329 citations

Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics

2001 • 305 citations

Data management and analysis for gene expression arrays

1998 • 300 citations

Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia.

2001 • 284 citations

Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer

2001 • 259 citations

Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma.

1994 • 244 citations

Genome changes and gene expression in human solid tumors

2000 • 192 citations

Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.

2000 • 172 citations

Effects of Ischemia on Gene Expression

2001 • 147 citations

CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking

2001 • 124 citations

Identification of gene expression patterns in superficial and invasive human bladder cancer.

2001 • 118 citations

CHASING THE CANCER DEMON

2000 • 109 citations

Gene expression profiling with oligonucleotide microarrays distinguishes World Health Organization grade of oligodendrogliomas.

2001 • 78 citations

Gene expression profiles of human endometrial cancer samples using a cDNA-expression array technique: assessment of an analysis method

2000 • 53 citations