Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

2001 • 2,288 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

The Leptin Receptor

1997 • 1,300 citations

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

2003 • 1,003 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

Activation of Downstream Signals by the Long Form of the Leptin Receptor

2000 • 800 citations

Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice

2004 • 716 citations

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels

1997 • 631 citations

Key enzyme in leptin-induced anorexia

2001 • 574 citations

Coexpression of Leptin Receptor and Preproneuropeptide Y mRNA in Arcuate Nucleus of Mouse Hypothalamus

1996 • 473 citations

Insulin Activation of Phosphatidylinositol 3-Kinase in the Hypothalamic Arcuate Nucleus

2003 • 458 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 382 citations

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

1999 • 374 citations

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

2004 • 373 citations

Chemical characterization of leptin-activated neurons in the rat brain

2000 • 358 citations

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

2003 • 320 citations

Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset

2004 • 264 citations

Arctic waders are not capital breeders

2001 • 262 citations

A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding

2002 • 239 citations

Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression

2003 • 212 citations

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1997 • 204 citations

PI3K integrates the action of insulin and leptin on hypothalamic neurons

2005 • 190 citations

Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATP channel activation.

2004 • 162 citations

Arcuate Nucleus-Specific Leptin Receptor Gene Therapy Attenuates the Obesity Phenotype of Koletsky (fak/fak) Rats

2003 • 156 citations

Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression

2000 • 149 citations

Intracellular Mechanisms Involved in Leptin Regulation of Sympathetic Outflow

2003 • 117 citations

Leptin depolarizes rat hypothalamic paraventricular nucleus neurons

1998 • 84 citations

Disruption of Arcuate/Paraventricular Nucleus Connections Changes Body Energy Balance and Response to Acute Stress

2000 • 83 citations

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic trh Gene Expression by Leptin

2004 • 78 citations

Central Administration of Neuropeptide Y Reduces α-Melanocyte-Stimulating Hormone-Induced Cyclic Adenosine 5′-Monophosphate Response Element Binding Protein (CREB) Phosphorylation in Pro-Thyrotropin-Releasing Hormone Neurons and Increases CREB Phosphorylation in Corticotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus

2002 • 65 citations

SOCS-3 expression in leptin-sensitive neurons of the hypothalamus of fed and fasted rats

2000 • 53 citations

Effects of Leptin Receptor Mutation onAgrpGene Expression in Fed and Fasted Lean and Obese (LA/N-fa^f) Rats¹

2000 • 34 citations