Development of anIn SituMouse Brain Perfusion Model and its Application tomdr1aP-Glycoprotein-Deficient Mice

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Physiological parameters in laboratory animals and humans.

1993 • 2,747 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

An in situ brain perfusion technique to study cerebrovascular transport in the rat

1984 • 538 citations

Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat

1978 • 444 citations

Purification of P-glycoprotein from plasma membrane vesicles of Chinese hamster ovary cell mutants with reduced colchicine permeability.

1979 • 368 citations

Blood—Brain Barrier Glucose Transporter

1999 • 298 citations

Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.

1976 • 211 citations

P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity

1997 • 203 citations

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides.

1994 • 201 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Introduction to the Blood-Brain Barrier

1998 • 180 citations

Measurement of Solute Transport Across the Blood–Brain Barrier in the Perfused Guinea Pig Brain: Method and Application to N‐Methyl‐α‐Aminoisobutyric Acid

1986 • 152 citations

Introduction to the blood-brain barrier : methodology, biology, and pathology

2006 • 128 citations

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

1997 • 123 citations

Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System

1996 • 112 citations

Kinetics of Regional Blood–Brain Barrier Transport and Brain Phosphorylation of Glucose and 2‐Deoxyglucose in the Barbiturate–Anesthetized Rat

1982 • 103 citations

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

1996 • 101 citations

Interaction of drugs with P-glycoprotein in brain capillaries

1995 • 100 citations

Entry of [3H]norepinephrine, [125I]albumin and evans blue from blood into brain following unilateral osmotic opening of the blood-brain barrier

1978 • 94 citations

Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

1988 • 85 citations

The putative blood-brain barrier transporter for the β-amyloid binding protein apolipoprotein j is saturated at physiological concentrations

1997 • 66 citations

Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine

1997 • 57 citations

Changes in the kinetics of the acidic amino acid brain and CSF uptake during development in the rat

1997 • 42 citations

Inhibition of Glucose-Induced Insulin Release by Xylazine*

1985 • 41 citations

Regional Blood Flow

1975 • 35 citations

Effect of pentobarbital on amino acid and urea flux in the isolated dog brain

1973 • 31 citations

Evaluation of anesthetic effects on parameters for the in situ rat brain perfusion technique

1998 • 24 citations

Developmental modulation of blood-brain-barrier glucose transport in the rabbit

1994 • 23 citations

Physiologically based pharmacokinetic models of 2',3'-dideoxyinosine.

1997 • 20 citations

Brain Uptake of L‐Tryptophan and Diazepam: The Role of Plasma Protein Binding

1989 • 19 citations

Influence of cerebral blood flow on tryptophan uptake into brain

1990 • 14 citations

Blood-brain glucose transfer in the mouse

1993 • 10 citations

P-glycoprotein, a guardian of the brain

1998 • 8 citations