Kinetic Analysis of In Vivo Receptor-Dependent Binding of Human Epidermal Growth Factor by Rat Tissues

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity.

1980 • 853 citations

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

Insulin and epidermal growth factor. Human fibroblast receptors related to deoxyribonucleic acid synthesis and amino acid uptake.

1975 • 367 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Regulation of Cell Proliferation by Epidermal Growth Factor

1983 • 235 citations

A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers.

1983 • 189 citations

A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat.

1977 • 185 citations

A comparison of the binding of epidermal growth factor to cultured granulosa and luteal cells.

1978 • 151 citations

Measurement of the distribution of cardiac output in unanesthetized rats

1971 • 148 citations

Physiologically Based Pharmacokinetic Model for β-Lactam Antibiotics I: Tissue Distribution and Elimanation Rates

1983 • 143 citations

Circadian Phase-Dependent Stimulatory Effects of Epidermal Growth Factor on Deoxyribonucleic Acid Synthesis in the Duodenum, Jejunum, Ileum, Caecum, Colon, and Rectum of the Adult Male Mouse*

1980 • 132 citations

Stimulation of sugar uptake in cultured fibroblasts by epidermal growth factor (EGF) and EGF‐binding arginine esterase

1976 • 121 citations

Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster.

1986 • 121 citations

Effect of urogastrone on gastric secretion and plasma gastrin levels in normal subjects.

1975 • 100 citations

The Isolation of the Urogastrones — Inhibitors of Gastric Acid Secretion — from Human Urine

1975 • 89 citations

Demonstration of specific receptors for EGF—urogastrone in isolated rat intestinal epithelial cells

1980 • 81 citations

Interaction of epidermal growth factor with adult rat liver parenchymal cells in primary culture

1980 • 74 citations

Circadian Stage-Dependent Effects of Epidermal Growth Factor on Deoxyribonucleic Acid Synthesis in Ten Different Organs of the Adult Male Mouse*

1981 • 50 citations

Biological effects of biosynthetic human EGF on the growth of mammalian cells in vitro

1985 • 46 citations

Pharmacokinetic evidence for the occurrence of extrahepatic conjugative metabolism of p-nitrophenol in rats

1982 • 35 citations

Overproduction of human epidermal growth factor/urogastrone in Escherichia coli and demonstration of its full biological activities

1985 • 26 citations

Binding of human epidermal growth factor to tissue homogenates of the rat.

1987 • 22 citations

Heterogeneity of 125I-labeled epidermal growth factor

1985 • 10 citations

Theoretical interpretation of extraction (in brain) of peptides including concentration variations

1984 • 5 citations

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