CpG-Containing Oligonucleotides Are Efficient Adjuvants for Induction of Protective Antiviral Immune Responses with T-Cell Peptide Vaccines

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Receptor-Dependent Mechanisms of Cell Stimulation by Bacterial Endotoxin

1995 • 1,436 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

The Influence of Antigen Organization on B Cell Responsiveness

1993 • 701 citations

CpG islands as gene markers in the vertebrate nucleus

1987 • 687 citations

Baculovirus Expression Vectors: the Requirements for High Level Expression of Proteins, Including Glycoproteins

1987 • 677 citations

Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo

1996 • 614 citations

Macrophages ingest and are activated by bacterial DNA.

1996 • 579 citations

The Virology and Immunobiology of Lymphocytic Choriomeningitis Virus Infection

1980 • 554 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

1991 • 460 citations

CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis.

1998 • 457 citations

Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides.

1996 • 438 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock

1997 • 422 citations

CpG‐containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants

1997 • 390 citations

DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth

1992 • 370 citations

Cutting Edge: CpG Oligodeoxynucleotides Trigger Protective and Curative Th1 Responses in Lethal Murine Leishmaniasis

1998 • 349 citations

CpG Motifs in Bacterial DNA Activate Leukocytes Through the pH-Dependent Generation of Reactive Oxygen Species

1998 • 331 citations

Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1991 • 321 citations

Immune Activation by Bacterial DNA: A New Genetic Code

1996 • 304 citations

Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway.

1996 • 288 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

1991 • 263 citations

Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

1997 • 248 citations

A T cell-independent mechanism of macrophage activation by interferon-gamma.

1987 • 239 citations

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity

1994 • 229 citations

Vaccinia Virus Recombinants: Expression of VSV Genes and Protective Immunization of Mice and Cattle

1985 • 228 citations

Crucial Role of Interferon Consensus Sequence Binding Protein, but neither of Interferon Regulatory Factor 1 nor of Nitric Oxide Synthesis for Protection Against Murine Listeriosis

1997 • 164 citations

Antiviral protection by virus-immune cytotoxic T cells: infected target cells are lysed before infectious virus progeny is assembled.

1977 • 161 citations

Impairment and delay of neutralizing antiviral antibody responses by virus-specific cytotoxic T cells.

1993 • 134 citations

Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus

1988 • 125 citations

Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination

1997 • 109 citations

Antiviral protection by CD8+ versus CD4+ T cells. CD8+ T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL.

1991 • 95 citations

Glycosylation is not required for the fusion activity of the G protein of vesicular stomatitis virus in insect cells

1989 • 45 citations

Characterization of T-helper epitopes of the glycoprotein of vesicular stomatitis virus

1994 • 39 citations

T helper cell unresponsiveness: Rapid induction in antigen-transgenic and reversion in non-transgenic mice

1994 • 33 citations