Differential expression of B7 co-stimulatory molecules by astrocytes correlates with T cell activation and cytokine production

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Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue.

1980 • 3,822 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1992 • 1,200 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells.

1994 • 498 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

1986 • 471 citations

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production.

1993 • 357 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

1997 • 284 citations

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

1998 • 275 citations

Microglia induce CD4 T lymphocyte final effector function and death.

1996 • 266 citations

Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen

1993 • 260 citations

Human peripheral blood dendritic cell subsets. Isolation and characterization of precursor and mature antigen-presenting cells.

1994 • 252 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis.

1998 • 229 citations

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

1995 • 205 citations

Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?

1998 • 195 citations

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis.

1995 • 194 citations

Cutting Edge Commentary: Chemokine Regulation of Experimental Autoimmune Encephalomyelitis: Temporal and Spatial Expression Patterns Govern Disease Pathogenesis

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Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.

1986 • 178 citations

Kinetics of Expression of Costimulatory Molecules and Their Ligands in Murine Relapsing Experimental Autoimmune Encephalomyelitis In Vivo

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Antigen presentation in the central nervous system. The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed.

1994 • 168 citations

B7/BB‐1 antigen expression on adult human microglia studied in vitro and in situ

1994 • 167 citations

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

1992 • 160 citations

Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.

1995 • 160 citations

IFN-gamma-activated primary murine astrocytes express B7 costimulatory molecules and prime naive antigen-specific T cells.

1997 • 153 citations

CD28 engagement and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo.

1997 • 148 citations

T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture

1995 • 143 citations

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia

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Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis.

1993 • 119 citations

Interaction between myelin basic protein-sensitized T lymphocytes and murine cerebral vascular endothelial cells.

1986 • 117 citations

Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes.

1998 • 116 citations

Major histocompatibility complex-expressing nonhematopoietic astroglial cells prime only CD8+ T lymphocytes: astroglial cells as perpetuators but not initiators of CD4+ T cell responses in the central nervous system.

1991 • 107 citations

Human astrocytes are only partially competent antigen presenting cells

1994 • 106 citations

Establishment and neurite outgrowth properties of neonatal and adult rat olfactory bulb glial cell lines

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Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-γ-Activated SJL/J Astrocytes

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Antigen presentation by astrocytes primes rat T lymphocytes for apoptotic cell death

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Multiple sclerosis Immunomodulatory effects of human astrocytes on T cells

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1986 • 78 citations

Reciprocal expression of co‐stimulatory molecules, B7‐1 and B7‐2, on murine T cells following activation

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Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system

1994 • 74 citations

Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines

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Antigen Presentation in the Central Nervous System

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Proliferation of human T lymphocytes induced with superantigens is not dependent on costimulation by the CD28 counter-receptor B7.

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B7-2 blockade enhances T cell responses to Leishmania donovani.

1997 • 56 citations

B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression.

1997 • 55 citations

Treatment of PL/J mice with the superantigen, staphylococcal enterotoxin B, prevents development of experimental allergic encephalomyelitis

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Immortalization of immature and mature mouse astrocytes with SV40 T antigen

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Induction of antigen presentation ability in purified cultures of astroglia by interferon-gamma.

1986 • 42 citations

Distinct roles for B7-1 and B7-2 determinants during priming of effector CD8+ Tc1 and regulatory CD4+ Th2 cells for contact hypersensitivity.

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Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen.

1995 • 36 citations

Costimulation of Superantigen-Activated T Lymphocytes by Autologous Dendritic Cells Is Dependent on B7

1994 • 33 citations

Detailed analysis of early immunopathologic events during lesion formation in acute experimental autoimmune encephalomyelitis

1989 • 32 citations

Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.

1992 • 31 citations

Dissociation of antigen-presenting capacity of astrocytes for peptide-antigens versus superantigens.

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T Helper Subset Differentiation in the Absence of Invariant Chain

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Astrocytes express elements of the class II endocytic pathway and process central nervous system autoantigen for presentation to encephalitogenic T cells

1998 • 8 citations