Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine

1956 • 877 citations

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

1979 • 576 citations

Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits.

1982 • 537 citations

Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

1983 • 337 citations

Quantitative Relationship between Amount of Dietary Fat and Severity of Alcoholic Fatty Liver

1970 • 313 citations

Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

1985 • 311 citations

Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

1981 • 304 citations

Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

1984 • 301 citations

Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

1980 • 286 citations

Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

1976 • 262 citations

Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols.

1982 • 235 citations

Sex difference of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats

1983 • 233 citations

Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes.

1985 • 221 citations

Purification and characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls

1982 • 217 citations

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.

1985 • 215 citations

Induction of kidney tumours in the rat with dimethylnitrosamine (N‐nitrosodimethylamine)

1962 • 209 citations

Carbon tetrachloride‐induced lipid peroxidation dependent on an ethanol‐inducible form of rabbit liver microsomal cytochrome P‐450

1985 • 204 citations

Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver

1975 • 186 citations

Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes

1979 • 181 citations

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

1986 • 173 citations

Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a

1986 • 158 citations

Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption.

1981 • 156 citations

Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen

1983 • 146 citations

The induction and competitive inhibition of a high affinity microsomal nitrosodimethylamine demethylase by ethanol

1982 • 127 citations

Immunochemical relatedness of rat hepatic microsomal cytochromes P-450c and P-450d.

1982 • 121 citations

Age- and sex-related expression of cytochromes P450f and P450g in rat liver

1986 • 110 citations

N-demethylation of N-nitrosodimethylamine catalyzed by purified rat hepatic microsomal cytochrome P-450: Isozyme specificity and role of cytochrome b5

1986 • 103 citations

Characterization of nine monoclonal antibodies against rat hepatic cytochrome P-450c. Delineation of at least five spatially distinct epitopes.

1984 • 101 citations

Repressible and inducible enzymic forms of dimethylnitrosamine-demethylase

1977 • 84 citations

Immunochemical identification of cytochrome P-450 isozyme 3a (P-450ALC) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol.

1986 • 81 citations

Induction of a high affinity nitrosamine demethylase in rat liver microsomes by acetone and isopropanol

1983 • 78 citations

Pyrazole-induced cytochrome P-450 in rat liver microsomes: An isozyme with high affinity for dimethylnitrosamine

1981 • 72 citations

Demethylation and denitrosation of nitrosamines by cytochrome P-450 isozymes

1985 • 71 citations

Monoclonal antibodies distinguish among isozymes of the cytochrome P-450b subfamily

1985 • 70 citations

Factors affecting metabolism and mutagenicity of dimethylnitrosamine and diethylnitrosamine.

1975 • 69 citations

Enhanced Hepatic Microsomal Activity by Pretreatment of Rats with Acetone or Isopropanol

1973 • 67 citations

Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment.

1984 • 65 citations

Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls

1979 • 57 citations

Some Studies on the Metabolism in vitro of Dimethylnitrosamine by Rat Liver

1974 • 50 citations

Induction of the ethanol-inducible form of rabbit liver microsomal cytochrome P-450 by inhibitors of alcohol dehydrogenase

1984 • 46 citations

Repression of dimethylnitrosamine-demethylase by typical inducers of microsomal mixed-function oxidases

1975 • 44 citations

Induction of microsomal dimethylnitrosamine demethylase by pyrazole

1982 • 36 citations

Stimulation of microsomal dimethylnitrosamine-N-demethylase by pretreatment of mice with acetone

1978 • 35 citations

Investigations into the hepatic metabolism of dimethylnitrosamine in the rat

1975 • 35 citations

Use of high concentrations of dimethylnitrosamine in bacterial lethality, mutagenesis, and enzymological studies.

1978 • 28 citations

Age-Dependence of Hepatic Dimethylnitrosamine-Demethylase Activity in the Rat2

1976 • 26 citations

Comparative studies on the effects of various microsomal enzyme inducers on the N-demethylation of dimethylnitrosamine

1981 • 23 citations

Rat liver microsomal induction of the oxidation of drugs and alcohols, and sodium dodecyl sulfate-gel profiles after in vivo treatment with pyrazole or 4-methylpyrazole.

1986 • 20 citations

Stimulation of hepatic microsomal aniline p-hydroxylase activity by dimethyl sulfoxide administration to rats

1970 • 16 citations

Induction of Dimethylnitrosamine-demethylase by Polar Solvents

1980 • 10 citations