Interactions among ACE, kinins and NO
Data up to Jan 2025
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Abstract
References (178)
Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
1994 • 2,753 citations
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
1989 • 2,183 citations
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
1995 • 2,075 citations
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
1989 • 1,837 citations
Hypercholesterolemia increases endothelial superoxide anion production.
1993 • 1,799 citations
Bioregulation of kinins: kallikreins, kininogens, and kininases.
1992 • 1,732 citations
Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide
1992 • 1,635 citations
Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease
1996 • 1,065 citations
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
1992 • 822 citations
Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
1991 • 813 citations
Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.
1998 • 799 citations
Endogenous nitric oxide: physiology, pathology and clinical relevance
1991 • 766 citations
Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.
1992 • 697 citations
Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors.
1995 • 642 citations
Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.
1997 • 603 citations
Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.
1990 • 527 citations
Chronic inhibition of nitric oxide production accelerates neointima formation and impairs endothelial function in hypercholesterolemic rabbits.
1994 • 501 citations
Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion
1995 • 479 citations
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
1996 • 473 citations
Expression of Multiple Isoforms of Nitric Oxide Synthase in Normal and Atherosclerotic Vessels
1997 • 468 citations
Effect of Bradykinin-Receptor Blockade on the Response to Angiotensin-Converting–Enzyme Inhibitor in Normotensive and Hypertensive Subjects
1998 • 446 citations
Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease
1996 • 431 citations
Antiatherogenic effect of captopril in the Watanabe heritable hyperlipidemic rabbit.
1990 • 419 citations
Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.
1996 • 413 citations
Nitric oxide attenuates cardiac myocyte contraction
1993 • 405 citations
Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide
1996 • 401 citations
AT 2 Receptor Stimulation Increases Aortic Cyclic GMP in SHRSP by a Kinin-Dependent Mechanism
1998 • 393 citations
Reduced Endothelial Nitric Oxide Synthase Expression and Production in Human Atherosclerosis
1998 • 386 citations
Basal nitric oxide synthesis in essential hypertension
1997 • 374 citations
Ramiprilat enhances endothelial autacoid formation by inhibiting breakdown of endothelium-derived bradykinin.
1991 • 361 citations
Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats.
1998 • 350 citations
Effect of local intra-arterial NG-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal.
1992 • 343 citations
Alterations of Nitric Oxide Synthase Expression With Aging and Hypertension in Rats
1998 • 335 citations
Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats.
1997 • 332 citations
Role of Bradykinin in Mediating Vascular Effects of Angiotensin-Converting Enzyme Inhibitors in Humans
1997 • 332 citations
Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats
1995 • 304 citations
Endothelial Dysfunction Coincides With an Enhanced Nitric Oxide Synthase Expression and Superoxide Anion Production
1997 • 300 citations
Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta
1995 • 287 citations
Nitric Oxide
1995 • 266 citations
Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.
1992 • 264 citations
Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation
1995 • 259 citations
A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: Angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11
1993 • 251 citations
Role of endothelium-derived relaxing factor in regulation of renal hemodynamic responses
1990 • 250 citations
N-Domain–Specific Substrate and C-Domain Inhibitors of Angiotensin-Converting Enzyme
1998 • 246 citations
Release of nitric oxide by angiotensin‐(1–7) from porcine coronary endothelium: implications for a novel angiotensin receptor
1994 • 245 citations
Upregulation of Renal and Vascular Nitric Oxide Synthase in Young Spontaneously Hypertensive Rats
1998 • 245 citations
Angiotensin-(1–7) Augments Bradykinin-Induced Vasodilation by Competing With ACE and Releasing Nitric Oxide
1997 • 245 citations
Direct In Situ Measurement of Nitric Oxide in Mesenteric Resistance Arteries
1996 • 244 citations
Differential regulation of angiotensin peptide levels in plasma and kidney of the rat.
1991 • 240 citations
A specific B2‐bradykinin receptor antagonist HOE 140 abolishes the antihypertrophic effect of ramipril
1992 • 236 citations
Effects of angiotensin converting enzyme inhibitors and of hydralazine on endothelial function in hypertensive rats.
1990 • 234 citations
Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation.
1993 • 233 citations
Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension
1996 • 229 citations
Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats
1995 • 222 citations
The Angiotensin II Type 2 (AT2) Receptor Promotes Axonal Regeneration in the Optic Nerve of Adult Rats
1998 • 209 citations
Early Versus Delayed Angiotensin-Converting Enzyme Inhibition Therapy in Acute Myocardial Infarction
1997 • 207 citations
Kinins and Endothelial Control of Vascular Smooth Muscle
1995 • 206 citations
Reduction of infarct size by local angiotensin-converting enzyme inhibition is abolished by a bradykinin antagonist
1990 • 204 citations
Converting Enzyme Determines Plasma Clearance of Angiotensin-(1–7)
1998 • 198 citations
Molecular Regulation of the Bovine Endothelial Cell Nitric Oxide Synthase by Transforming Growth Factor–β 1
1995 • 194 citations
Endothelial cells cultured from human umbilical vein release ATP, substance P and acetylcholine in response to increased flow
1990 • 194 citations
ACE Inhibitors Promote Nitric Oxide Accumulation to Modulate Myocardial Oxygen Consumption
1997 • 188 citations
Aging-Associated Endothelial Dysfunction in Humans Is Reversed by L-Arginine
1996 • 176 citations
Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production
1998 • 166 citations
Chronic Angiotensin-Converting Enzyme Inhibition and Angiotensin II Type 1 Receptor Blockade
1997 • 166 citations
Angiotensin-(1-7) Potentiates the Hypotensive Effect of Bradykinin in Conscious Rats
1995 • 161 citations
Regulation of Nitric Oxide Production in Human Coronary Microvessels and the Contribution of Local Kinin Formation
1996 • 156 citations
Paracrine modulation of heart cell function by endothelial cells
1996 • 156 citations
Nitric Oxide Activity in the Atherosclerotic Human Coronary Circulation
1997 • 151 citations
Ramiprilat increases bradykinin outflow from isolated hearts of rat
1993 • 150 citations
Bradykinin peptides in kidney, blood, and other tissues of the rat.
1993 • 149 citations
Potentiation of the Actions of Bradykinin by Angiotensin I–Converting Enzyme Inhibitors
1997 • 144 citations
ACE-inhibition induces NO-formation in cultured bovine endothelial cells and protects isolated ischemic rat hearts
1992 • 142 citations
Paracrine Systems in the Cardioprotective Effect of Angiotensin-Converting Enzyme Inhibitors on Myocardial Ischemia/Reperfusion Injury in Rats
1996 • 142 citations
A local kallikrein-kinin system is present in rat hearts.
1994 • 141 citations
Reduction of Myocardial Infarct Size in Rabbits by Ramiprilat
1993 • 141 citations
Bovine Aortic Endothelial Cells Contain an Angiotensin-(1–7) Receptor
1997 • 135 citations
Endothelium‐derived relaxing factor and atriopeptin II elevate cyclic GMP levels in pig aortic endothelial cells
1988 • 130 citations
Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells
1991 • 127 citations
Increased Activity of Constitutive Nitric Oxide Synthase in Cardiac Endothelium in Spontaneous Hypertension
1995 • 127 citations
Long-term ACE Inhibition Doubles Lifespan of Hypertensive Rats
1997 • 126 citations
Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.
1992 • 119 citations
Chronic <scp>l</scp> -Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats
1996 • 118 citations
Agonist-induced redistribution of bradykinin B 2 receptor in caveolae
1998 • 116 citations
Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits.
1993 • 113 citations
Angiotensin II-induced hypertrophy of adult rat cardiomyocytes is blocked by nitric oxide
1998 • 112 citations
Role of Kinins in the Cardioprotective Effect of Preconditioning
1997 • 111 citations
Antiatherosclerotic and Antioxidative Effects of Captopril in Apolipoprotein E-Deficient Mice
1998 • 111 citations
Angiotensin-(1-7) and Nitric Oxide Interaction in Renovascular Hypertension
1995 • 108 citations
The Conformational Change Responsible for AT1 Receptor Activation Is Dependent upon Two Juxtaposed Asparagine Residues on Transmembrane Helices III and VII
1997 • 107 citations
Chronic kinin receptor blockade attenuates the antihypertensive effect of ramipril.
1992 • 107 citations
Endothelial dysfunction in spontaneously hypertensive rats
1997 • 106 citations
Endothelial constitutive nitric oxide synthase protein and mRNA increased in rabbit atherosclerotic aorta despite impaired endothelium-dependent vascular relaxation.
1996 • 105 citations
Modulation of angiotensin‐converting enzyme by nitric oxide
1998 • 104 citations
Bradykinin stimulates the production of cyclic GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells.
1990 • 101 citations
Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery.
1998 • 100 citations
Some Old and Some New Ideas on Kinin Metabolism
1990 • 99 citations
Acute effects of nitric oxide and cyclic GMP on human myocardial contractility.
1997 • 98 citations
Potentiation by ACE inhibitors of the dilator response to bradykinin in the coronary microcirculation: interaction at the receptor level
1994 • 96 citations
Angiotensin-Converting Enzyme Inhibitors Potentiate Preconditioning Through Bradykinin B2Receptor Activation in Human Heart
1997 • 95 citations
Preservation of Endothelial Function by Ramipril in Rabbits on a Long-Term Atherogenic Diet
1991 • 94 citations
Differential Effects of Kinins on Cardiomyocyte Hypertrophy and Interstitial Collagen Matrix in the Surviving Myocardium After Myocardial Infarction in the Rat
1997 • 93 citations
Reduced Basal NO-mediated Dilation and Decreased Endothelial NO-synthase Expression in Coronary Vessels of Spontaneously Hypertensive Rats
1997 • 92 citations
Angiotensin-Converting Enzyme Inhibition in Infarct-Induced Heart Failure in Rats: Bradykinin Versus Angiotensin II
1994 • 91 citations
Angiotensin-(1-7) and the Rat Aorta: Modulation by the Endothelium
1997 • 89 citations
Changes in the Baroreflex Control of Heart Rate Produced by Central Infusion of Selective Angiotensin Antagonists in Hypertensive Rats
1996 • 88 citations
Angiotensin-Converting Enzyme Inhibition Alters Nitric Oxide and Superoxide Release in Normotensive and Hypertensive Rats
1997 • 83 citations
Alterations to the nitric oxide pathway in the spontaneously hypertensive rat
1998 • 83 citations
Endothelial regulation of cyclic GMP and vascular responses in hypertension.
1988 • 82 citations
Mechanism of vasoconstriction induced by chronic inhibition of nitric oxide in rats.
1994 • 82 citations
Potentiation of the Hypotensive Effect of Bradykinin by Short-term Infusion of Angiotensin-(1-7) in Normotensive and Hypertensive Rats
1997 • 81 citations
Pressor and Reflex Sensitivity Is Altered in Spontaneously Hypertensive Rats Treated With Angiotensin-(1-7)
1995 • 78 citations
Intravascular and interstitial degradation of bradykinin in isolated perfused rat heart
1997 • 76 citations
Angiotensin-(1-7) Induces Bradykinin-Mediated Hypotensive Responses in Anesthetized Rats
1997 • 74 citations
Chronic effects of early started angiotensin converting enzyme inhibition and angiotensin AT1-receptor subtype blockade in rats with myocardial infarction: role of bradykinin
1998 • 74 citations
Increased Release of NO During Ischemia Reduces Myocardial Contractility and Improves Metabolic Dysfunction
1996 • 74 citations
Long-term low-dose angiotensin converting enzyme inhibitor treatment increases vascular cyclic guanosine 3',5'-monophosphate.
1993 • 73 citations
Increase of angiotensin converting enzyme gene expression in the hypertensive aorta.
1992 • 71 citations
ACE in three tunicae of rat aorta: expression in smooth muscle and effect of renovascular hypertension
1994 • 70 citations
ACE inhibitors are endothelium dependent vasodilators of coronary arteries during submaximal stimulation with bradykinin
1993 • 69 citations
Functional Effects of Endogenous Bradykinin in Congestive Heart Failure
1998 • 68 citations
Changes in Hemodynamics and Bradykinin Concentration in Coronary Sinus Blood in Experimental Coronary Artery Occlusion
1977 • 68 citations
Contribution of angiotensin-converting enzyme to the cardiac metabolism of bradykinin: an interspecies study
1997 • 66 citations
Early Versus Delayed Angiotensin-Converting Enzyme Inhibition in Experimental Chronic Heart Failure
1997 • 65 citations
ACE inhibitor potentiation of bradykinin‐induced venoconstriction
1997 • 62 citations
Bradykinin Blocks Angiotensin II–Induced Hypertrophy in the Presence of Endothelial Cells
1998 • 59 citations
Improved Survival in Rats Administered NG-Nitro L-Arginine Methyl Ester Due to Converting Enzyme Inhibition
1996 • 59 citations
Increases in endothelial cyclic AMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF)
1992 • 57 citations
Beneficial Effects of Bradykinin on Myocardial Energy Metabolism and Infarct Size
1997 • 57 citations
Nitric oxide synthase (NOS3) and contractile responsiveness to adrenergic and cholinergic agonists in the heart. Regulation of NOS3 transcription in vitro and in vivo by cyclic adenosine monophosphate in rat cardiac myocytes.
1996 • 57 citations
Effect of enalaprilat on bradykinin and des‐Arg9‐bradykinin release following reperfusion of the ischaemic rat heart
1995 • 57 citations
Converting enzyme inhibition in kinin-deficient brown Norway rats.
1990 • 55 citations
Ramipril Prevents Endothelial Dysfunction Induced by Oxidized Low-Density Lipoproteins
1997 • 53 citations
Cardioprotection by angiotensin converting enzyme inhibitors - the experimental evidence
1994 • 53 citations
GTP gamma S loading of endothelial cells stimulates phospholipase C and uncouples ATP receptors
1988 • 51 citations
Different B1 kinin receptor expression and pharmacology in endothelial cells of different origins and species.
1997 • 50 citations
Endothelial function in spontaneously hypertensive rats: influence of quinapril treatment
1995 • 50 citations
Regulation by cAMP of Post-translational Processing and Subcellular Targeting of Endothelial Nitric-oxide Synthase (Type 3) in Cardiac Myocytes
1997 • 48 citations
Role of Bradykinin in Chronic Antihypertensive Actions of Ramipril in Different Hypertension Models
1992 • 47 citations
Angiotensin I-Converting Enzyme Inhibitors Potentiate Bradykinin’s Inotropic Effects Independently of Blocking Its Inactivation
1997 • 46 citations
Distribution and metabolism of angiotensin I and II in the blood vessel wall.
1992 • 45 citations
cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue
1996 • 45 citations
Cardiovascular Hypertrophy: Role of Angiotensin II and Bradykinin
1996 • 42 citations
Enhancement of cytosolic calcium, prostacyclin and nitric oxide by bradykinin and the ACE inhibitor ramiprilat in porcine brain capillary endothelial cells
1994 • 42 citations
Endothelium-Derived Bradykinin
1993 • 41 citations
Induction of prostacyclin biosynthesis is closely associated with increased guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium.
1986 • 40 citations
Modulation of agonist‐induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP
1991 • 38 citations
Converting enzyme inhibitor ramipril stimulates prostacyclin synthesis by isolated rat aorta: Evidence for a kinin-dependent mechanism
1986 • 37 citations
Nitric oxide modulates cardiac contractility and oxygen consumption without changing contractile efficiency
1998 • 37 citations
Endothelium-Dependent Relaxation Is Not Uniformly Impaired in Chronic Heart Failure
1997 • 36 citations
cAMP attenuates autacoid release from endothelial cells: relation to internal calcium
1990 • 35 citations
Comparison of the Antiatherogenic Effects of Isradipine and Ramipril in Cholesterol-Fed Rabbits
1994 • 34 citations
Relaxation of Isolated Coronary Arteries by Angiotensin-Converting Enzyme Inhibitors: Role of Endothelium-Derived Kinins
1993 • 33 citations
Binding at an NFI Site Is Modulated by Cyclic AMP–Dependent Activation of Myelin Basic Protein Gene Expression
1993 • 31 citations
Up‐regulation of endothelial nitric oxide synthase expression by cyclic guanosine 3′,5′‐monophosphate
1995 • 29 citations
Effect of Cilazapril and Indomethacin on Endothelial Dysfunction in the Aortas of Spontaneously Hypertensive Rats
1993 • 29 citations
Upregulation of angiotensin converting enzyme by atrial natriuretic peptide and cyclic GMP in human endothelial cells
1998 • 27 citations
Endothelium-mediated vasodilation during ACE inhibition
1995 • 25 citations
Prostacyclin-dependent cyclic AMP formation in endothelial cells
1993 • 24 citations
Release of Endothelium-Derived Relaxing Factor is Inhibited by 8-Bromo-Cyclic Guanosine Monophosphate
1988 • 23 citations
Differential effects of L-NAME on blood pressure and heart rate responses to acetylcholine and bradykinin in cynomolgus primates.
1995 • 23 citations
Kinin- and Non-Kinin-Mediated Interactions of Converting Enzyme Inhibitors with Vasoactive Hormones
1990 • 22 citations
Increased release of nitric oxide in ischemic hearts after exercise in patients with effort angina
1998 • 21 citations
Impairment of cGMP- and cAMP-mediated vasorelaxations in rats with chronic heart failure
1996 • 19 citations
The Role of Kinins in the Antihypertensive and Cardioprotective Effects of ACE Inhibitors
1997 • 19 citations
Converting enzyme inhibition and vascular prostacyclin synthesis: effect of kinin receptor antagonism
1990 • 19 citations
Direct Measurement of Nitric Oxide Release from Cultured Endothelial Cells Stimulated by Bradykinin or Ramiprilat
1996 • 18 citations
Comparison of the Antiatherogenic Effects of Isradipine and Ramipril in Cholesterol-Fed Rabbits
1994 • 17 citations
Ramipril‐induced delayed myocardial protection against free radical injury involves bradykinin B2 receptor‐NO pathway and protein synthesis
1998 • 17 citations
Cilazapril reverses endothelium-dependent vasodilator response to acetylcholine in mesenteric artery from spontaneously hypertensive rats*
1995 • 14 citations
Arterial Responses to Bradykinin after Ramipril Therapy in Experimental Hypertension
1997 • 13 citations
Previous exposure to bradykinin unmasks an endothelium-dependent relaxation to the converting enzyme inhibitor trandolaprilat in isolated canine coronary arteries.
1995 • 13 citations
Comparison of Felodipine and Hydrochlorothiazide for the Treatment of Mild to Moderate Hypertension in Black Africans
1990 • 6 citations
Low-density lipoproteins
1971 • 6 citations
Doctors and the plague.
1996 • 2 citations
Hypercholesterolaemia
1998 • 2 citations
5.3 Nitric oxide and superoxide balance in a model of genetic hypertension
1997 • 1 citations
Late ace inhibitor treatment protects old SHR from cardiovascular death
1998 • 1 citations