A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

A novel method for real time quantitative RT-PCR.

1996 • 2,093 citations

Tumor spectrum analysis in p53-mutant mice

1994 • 2,034 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

1996 • 1,580 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1998 • 1,538 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Nucleolar Arf sequesters Mdm2 and activates p53

1999 • 937 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1999 • 828 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

1997 • 428 citations

Cell cycle-dependent activation of Ras

1996 • 389 citations

Abnormalities of the p53 tumour suppressor gene in human pancreatic cancer

1991 • 375 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

1995 • 316 citations

Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice

1987 • 271 citations

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

1998 • 197 citations

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

1997 • 168 citations

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

1986 • 168 citations

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors

1996 • 122 citations

Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.

1995 • 79 citations