TGF-β1 Inhibits T-bet Induction by IFN-γ in Murine CD4+ T Cells through the Protein Tyrosine Phosphatase Src Homology Region 2 Domain-Containing Phosphatase-1

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Interferon-γ: an overview of signals, mechanisms and functions

2003 • 3,785 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Regulation of JAK–STAT signalling in the immune system

2003 • 1,313 citations

Molecular Mechanisms RegulatinG Th1 Immune Responses

2003 • 1,005 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Transforming growth factor-β in T-cell biology

2002 • 787 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

2001 • 743 citations

Stat1-dependent and -independent pathways in IFN-γ-dependent signaling

2002 • 545 citations

Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

2002 • 501 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

2000 • 320 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

2003 • 258 citations

Stat1-independent regulation of gene expression in response to IFN-γ

2001 • 243 citations

Antagonistic Regulation of Type I Collagen Gene Expression by Interferon-γ and Transforming Growth Factor-β

2001 • 226 citations

Negative regulators of cytokine signal transduction

1999 • 224 citations

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.

1996 • 214 citations

Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages.

1997 • 211 citations

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency

1997 • 163 citations

TGF-β1 Uses Distinct Mechanisms to Inhibit IFN-γ Expression in CD4+ T Cells at Priming and at Recall: Differential Involvement of Stat4 and T-bet

2005 • 154 citations

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells

1998 • 129 citations

TGF-beta inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes.

1997 • 127 citations

TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.

1997 • 127 citations

TGF-beta inhibits IL-12-induced activation of Jak-STAT pathway in T lymphocytes.

1998 • 124 citations

TGF-β Inhibits IL-12-Induced Activation of Jak-STAT Pathway in T Lymphocytes

1998 • 107 citations

Peptide-Specific CD8 T Regulatory Cells Use IFN-γ to Elaborate TGF-β-Based Suppression

2005 • 100 citations

Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-β1-Deficient Mice Develop Necroinflammatory IFN-γ-Dependent Hepatitis

2001 • 90 citations

Suppression of IL-2-Induced T Cell Proliferation and Phosphorylation of STAT3 and STAT5 by Tumor-Derived TGFβ Is Reversed by IL-15

2001 • 78 citations

The Smad3 Protein Is Involved in TGF-β Inhibition of Class II Transactivator and Class II MHC Expression

2001 • 74 citations

Growth arrest induced by transforming growth factor beta 1 is accompanied by protein phosphatase activation in human keratinocytes

1991 • 73 citations

TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression.

1995 • 55 citations

The role of protein tyrosine phosphatase SHP-1 in the regulation of IFN-gamma signaling in neural cells.

1996 • 48 citations

Dysregulation of IFN-γ Signaling Pathways in the Absence of TGF-β1

2002 • 40 citations

Necroinflammatory Liver Disease in BALB/c Background, TGF-β1-Deficient Mice Requires CD4+ T Cells

2003 • 40 citations

TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs.

1999 • 33 citations

TGF-β ABROGATES TCR-MEDIATED SIGNALING BY UPREGULATING TYROSINE PHOSPHATASES IN T CELLS

2001 • 33 citations

TGF-β Does Not Inhibit IL-12- and IL-2-Induced Activation of Janus Kinases and STATs

1999 • 30 citations

Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-β1 is mediated by caspase-dependent and -independent processes

2002 • 27 citations

Transforming growth factor-β1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells

2001 • 21 citations

Abnormal Th1 Cell Differentiation and IFN-γ Production in T Lymphocytes from Motheaten Viable Mice Mutant for Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-1

2005 • 19 citations