A recombinant minigene vaccine containing a nonameric cytotoxic-T-lymphocyte epitope confers limited protection against Listeria monocytogenes infection

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

Listeria monocytogenes, a food-borne pathogen

1991 • 2,442 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Immunity to Intracellular Bacteria

1993 • 1,085 citations

Vaccinia virus expression vector: coexpression of beta-galactosidase provides visual screening of recombinant virus plaques.

1985 • 789 citations

In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2

1987 • 714 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Transposon mutagenesis as a tool to study the role of hemolysin in the virulence of Listeria monocytogenes

1986 • 431 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

REQUIREMENT OF THYMUS (T) LYMPHOCYTES FOR RESISTANCE TO LISTERIOSIS

1972 • 352 citations

Natural Immunity: A T‐Cell‐Independent Pathway of Macrophage Activation, Defined in the scid Mouse

1991 • 321 citations

Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes

1988 • 286 citations

The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis

1995 • 263 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

Recombinant Listeria monocytogenes as a live vaccine vehicle for the induction of protective anti-viral cell-mediated immunity.

1995 • 229 citations

CD8+ T cell-mediated protection against an intracellular bacterium by perforin-dependent cytotoxicity

1994 • 229 citations

Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium.

1991 • 200 citations

Intracellular growth of Listeria monocytogenes as a prerequisite for in vivo induction of T cell-mediated immunity.

1987 • 182 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

Direct sequence identification and kinetic analysis of an MHC class I-restricted Listeria monocytogenes CTL epitope.

1994 • 161 citations

Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

1988 • 155 citations

Detection of Listeria monocytogenes in cheese with the magnetic immuno-polymerase chain reaction assay

1993 • 138 citations

Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity

1989 • 138 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection

1989 • 127 citations

CD8 T cells can protect against an intracellular bacterium in an interferon gamma-independent fashion.

1992 • 122 citations

Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine.

1992 • 116 citations

THE EFFECT OF ANTI-LYMPHOCYTE GLOBULIN ON CELL-MEDIATED RESISTANCE TO INFECTION

1969 • 112 citations

CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.

1995 • 105 citations

Antigen-specific Lyt-2+ cytolytic T lymphocytes from mice infected with the intracellular bacterium Listeria monocytogenes.

1986 • 94 citations

Listeriolysin O is a target of the immune response to Listeria monocytogenes.

1992 • 79 citations

Attenuated Listeria monocytogenes as a live vector for induction of CD8⁺ T cells in vivo: a study with the nucleoprotein of the lymphocytic choriomeningitis virus

1995 • 76 citations

Induction of protective CD8⁺ T lymphocytes by an attenuated Listeria monocytogenes actA mutant

1992 • 73 citations

T cell recognition of listeriolysin O is induced during infection with Listeria monocytogenes.

1987 • 57 citations

Delivery of class I and class II MHC-restricted T-cell epitopes of listeriolysin of Listeria monocytogenes by attenuated Salmonella

1995 • 52 citations

Lyt-2+ T cell-mediated protection against listeriosis. Protection correlates with phagocyte depletion but not with IFN-gamma production.

1989 • 47 citations

Naturally occurring virulence-attenuated isolates ofListeria monocytogenescapable of inducing long term protection against infection by virulent strains of homologous and heterologous serotypes

1994 • 46 citations

Emergence of virus escape mutants after immunization with epitope vaccine

1995 • 40 citations

Antilisterial immunity includes specificity to listeriolysin O (LLO) and non-LLO-derived determinants

1994 • 29 citations

Evidence for a significant role of CD4+ T cells in adoptive immunity to Listeria monocytogenes in the liver.

1994 • 25 citations

Transfer of both protection and delayed-type hypersensitivity against live Listeria is mediated by the CD8⁺ T cell subset: a study with Listeria-specific T lymphocytes recovered from murine infected liver

1992 • 17 citations

The immunodominant peptide from listeriolysin in Quil A liposomes vaccinates CD8+ cytolytic T cells and confers protection to infection

1994 • 14 citations

Induction of Protective Immunity Using Minigenesa

1994 • 11 citations

A rapid and simple method for determining the DNA sequences of fragments inserted into vaccinia virus.

1993 • 6 citations