Emergence of virus escape mutants after immunization with epitope vaccine

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Vaccine-induced escape mutant of hepatitis B virus

1990 • 1,081 citations

Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

1991 • 1,025 citations

Matrix-assisted laser desorption/ionization mass spectrometry of biopolymers

1991 • 979 citations

Solid phase peptide synthesis; a practical approach

1991 • 772 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

RNA Virus Populations as Quasispecies

1992 • 523 citations

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen

1994 • 304 citations

Determination of the number of nonoverlapping antigenic areas on Hong Kong (H3N2) influenza virus hemagglutinin with monoclonal antibodies and the selection of variants with potential epidemiological significance

1980 • 261 citations

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

1994 • 226 citations

Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus

1993 • 185 citations

A "string-of-beads" vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge

1993 • 176 citations

Impaired cytotoxic T lymphocyte recognition due to genetic variations in the main immunogenic region of the human immunodeficiency virus 1 NEF protein.

1994 • 175 citations

T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.

1994 • 164 citations

[7] Amino acid analysis in the picomole range by precolumn derivatization and high-performance liquid chromatography

1983 • 160 citations

Endogenous peptides of a soluble major histocompatibility complex class I molecule, H-2Lds: sequence motif, quantitative binding, and molecular modeling of the complex.

1992 • 146 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

An Improved Method for Seed Germination

1935 • 128 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Similar frequencies of antigenic variants in Sendai, vesicular stomatitis, and influenza A viruses

1980 • 103 citations

Complete sequence of the S RNA of lymphocytic choriomeningitis virus (WE strain) compared to that of pichinde arenavirus

1985 • 102 citations

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax

1995 • 94 citations

Induction of protective cytotoxic T cells with viral proteins

1994 • 91 citations

Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus

1995 • 91 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge

1995 • 87 citations

In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes.

1991 • 86 citations

CTL Escape Viral Variants

1995 • 83 citations

In vivo persistence of a HIV‐1‐encoded HLA‐B27‐restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity

1991 • 78 citations

Cytotoxic T lymphocytes do not appear to select for mutations in an immunodominant epitope of simian immunodeficiency virus gag.

1992 • 76 citations

Recovery from Acute Virus Infection

1988 • 70 citations

Neutralizing Antibody Response During Human Immunodeficiency Virus Type 1 Infection: Type and Group Specificity and Viral Escape

1993 • 67 citations

A New Method to Detect Lymphocytic Choriomeningitis Virus-Specific Antibody in Human Sera

1977 • 60 citations

Purification of recombinant antigenic epitopes of the human 68-kDa (U1) ribonucleoprotein antigen using the expression system pH6EX3 followed by metal chelating affinity chromatography

1992 • 55 citations

Diversity of Lymphocytic Choriomeningitis Virus: Variation Due to Replication of the Virus in the Mouse

1976 • 45 citations

Cytotoxic T lymphocytes (CTL) against a transforming gene product select for transformed cells with point mutations within sequences encoding CTL recognition epitopes.

1992 • 44 citations

Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic T-lymphocyte activity: implications for control of viral disease

1992 • 42 citations

New vectors for direct cloning of PCR products

1993 • 42 citations

Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope.

1992 • 39 citations

Lytic and Turbid Plaque-Type Mutants of Lymphocytic Choriomeningitis Virus as a Cause of Neurological Disease or Persistent Infection

1971 • 35 citations

CD8+ T lymphocyte-mediated antiviral immunity in mice as a result of injection of recombinant viral proteins.

1994 • 28 citations

Localization of two cytotoxic T lymphocyte epitopes and three anchoring residues on a single nonameric peptide that binds to H‐2L^d and is recognized by cytotoxic T lymphocytes against mouse tumor P815

1994 • 27 citations

Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins

1995 • 13 citations

The Outbreak of Poliomyelitis in Finland in 1984–1985: Significance of Antigenic Variation of Type 3 Polioviruses and Site Specificity of Antibody Responses in Antipolio Immunizations

1989 • 11 citations

Characterization of a virus variant produced by L cells persistently infected with lymphocytic choriomeningitis virus

1994 • 7 citations