CD40: A Pivotal Receptor In the Determination of Life/Death Decisions in B Lymphocytes

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Germinal Centers

1994 • 1,680 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice

1995 • 1,167 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

T Cell-Dependent B Cell Activation

1993 • 727 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

1995 • 470 citations

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

1995 • 454 citations

CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.

1990 • 453 citations

gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

1994 • 431 citations

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

1995 • 426 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Towards a comprehensive view of immunoglobulin class switching

1993 • 373 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

1993 • 354 citations

A novel RING finger protein interacts with the cytoplasmic domain of CD40.

1994 • 345 citations

Interleukin‐12 profoundly up‐regulates the synthesis of antigen‐specific complement‐fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo

1995 • 331 citations

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes.

1994 • 305 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members.

1995 • 299 citations

Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines.

1993 • 276 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells

1990 • 239 citations

Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

1994 • 238 citations

γ-Interferon is one of several direct B cell-maturing lymphokines

1984 • 237 citations

E2F-5, a New E2F Family Member That Interacts with p130 In Vivo

1995 • 232 citations

Endogenous interleukin 6 plays an obligatory role in interleukin 4‐dependent human IgE synthesis

1989 • 221 citations

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4.

1993 • 214 citations

Bcl-2 and Bcl-2-Related Proteins in Apoptosis Regulation

1995 • 210 citations

Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulation with IL-4 and anti-CD40.

1994 • 210 citations

DP and E2F proteins: coordinating transcription with cell cycle progression

1994 • 205 citations

Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes.

1995 • 201 citations

Induction of the transcription factors NF-кB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor

1995 • 192 citations

A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40

1995 • 177 citations

Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells.

1992 • 177 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

The role of bcl‐x_L in CD40‐mediated rescue from anti‐μ‐induced apoptosis in WEHI‐231 B lymphoma cells

1995 • 154 citations

Programmed cell death by bcl-2-dependent and independent mechanisms in B lymphoma cells.

1993 • 147 citations

Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells.

1994 • 145 citations

Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny.

1991 • 139 citations

CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein.

1994 • 134 citations

Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells.

1995 • 129 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Recombinant CD40 ligand stimulation of murine B cell growth and differentiation: cooperative effects of cytokines

1993 • 125 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

Stimulation of B-cell proliferation by membrane-associated molecules from activated T cells.

1988 • 98 citations

The regulation of T cell-dependent antibody formation in vitro by CD40 ligand and IL-2.

1993 • 97 citations

Immunoblot analysis of cellular expression of Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human peripheral blood and lymphoid tissues

1995 • 94 citations

T cell-dependent induction of NF-kappa B in B cells.

1993 • 93 citations

Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. A study with anti-IgM and anti-CDw40 antibodies.

1989 • 91 citations

Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40

1990 • 90 citations

Activation of human B cells. Comparison of the signal transduced by IL-4 to four different competence signals.

1989 • 90 citations

CD38 unresponsiveness of xid B cells implicates Bruton's tyrosine kinase (btk) as a regulator of CD38 induced signal transduction

1995 • 87 citations

Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms

1995 • 85 citations

T helper cell‐dependent B cell activation

1991 • 84 citations

CD40: A cytokine receptor in search of a ligand

1990 • 82 citations

Recombinant interferon-gamma inhibits the B cell proliferative response stimulated by soluble but not by Sepharose-bound anti-immunoglobulin antibody.

1985 • 77 citations

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells

1995 • 73 citations

Engagement of CD40 lowers the threshold for activation of resting B cells via antigen receptor

1993 • 71 citations

CD40 ligation induces lymphotoxin α gene expression in human B cells

1994 • 66 citations

Plastic‐immobilized anti‐μ or anti‐δ antibodies induce apoptosis in mature murine B lymphocytes

1994 • 65 citations

Protein tyrosine phosphorylation is mandatory for CD40‐mediated rescue of germinal center B cells from apoptosis

1993 • 60 citations

Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent.

1992 • 55 citations

B cells from CBA/N mice do not proliferate following ligation of CD40

1994 • 55 citations

Fas receptor expression on B‐lineage cells

1995 • 51 citations

CYCLOSPORINE-SENSITIVE AND CYCLOSPORINE-INSENSITIVE MODES OF B CELL STIMULATION

1988 • 48 citations

Interferon-γ Regulation of B Lymphocyte Differentiation: Activation of B Cells Is a Prerequisite for IFN-γ-Mediated Inhibition of B Cell Differentiation

1994 • 45 citations

Expression of bcl‐x during mouse B cell differentiation and following activation by various stimuli

1996 • 39 citations

X-linked agammaglobulinemia - gene cloning and future prospects

1993 • 37 citations

Lymphoma models for B-cell activation and tolerance: anti-immunoglobulin M treatment induces growth arrest by preventing the formation of an active kinase complex which phosphorylates retinoblastoma gene product in G1.

1995 • 31 citations

Lyb-5- B cells of CBA/N mice can be induced to synthesize DNA by culture with insolubilized but not soluble anti-Ig.

1983 • 29 citations

Properties of mouse CD40. Ligation of CD40 activates B cells via a Ca⁺⁺‐dependent, FK506‐sensitive pathway

1994 • 26 citations

Physiological cell death in B lymphocytes: I. Differential susceptibility of WEHI-231 sublines to anti-lg inducedphysiological cell death and lack of correlation with bcl-2 expression

1994 • 26 citations