Paradoxical effect of BW 301U, a lipophilic antifolate, on methotrexate-inhibitable deoxyuridine incorporation by human hematopoietic cells.

The Pharmacology and Clinical Use of Methotrexate

1983 • 769 citations

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

1980 • 350 citations

New Approaches to Cancer Chemotherapy with Methotrexate

1975 • 228 citations

Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.

1981 • 191 citations

Unstable Methotrexate Resistance in Human Small-Cell Carcinoma Associated with Double Minute Chromosomes

1983 • 178 citations

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.

1983 • 100 citations

Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase

1977 • 95 citations

Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.

1978 • 74 citations

Biochemical and chemotherapeutic studies on 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine (BW 301U), a novel lipid-soluble inhibitor of dihydrofolate reductase.

1982 • 66 citations

Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.

1982 • 65 citations

Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells.

1982 • 52 citations

Resistance to methotrexate in thymidylate synthetase-deficient mutants of cultured mouse mammary tumor FM3A cells.

1981 • 40 citations

Gene amplification and methotrexate resistance in cultured animal cells.

1980 • 17 citations

Gene amplification and altered enzymes as mechanisms for the development of drug resistance.

1983 • 15 citations

Deoxyuridine incorporation as a useful measure of methotrexate and metoprine uptake and metabolic effectiveness.

1979 • 10 citations

Methotrexate with thymidine, inosine, and allopurinol rescue: a phase I clinical study.

1981 • 8 citations

Transient induction of phenotypic resistance in human lymphoblastoid cells following sequential use of two antifolates.

1981 • 6 citations