Gene amplification and methotrexate resistance in cultured animal cells.

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Gene Amplification and Drug Resistance in Cultured Murine Cells

1978 • 317 citations

Structure and genomic organization of the mouse dihydrofolate reductase gene

1980 • 218 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells.

1976 • 171 citations

Have double minutes functioning centromeres?

2009 • 117 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Double Minutes in Human Carcinoma Cell Lines, With Special Reference to Breast Tumors<xref ref-type="fn" rid="fn2">2</xref>

1979 • 78 citations

Double minute chromosomes are not centromeric regions of the host chromosomes

2009 • 54 citations

Studies on the Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells

1979 • 36 citations