Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Requirement for V _α 14 NKT Cells in IL-12-Mediated Rejection of Tumors

1997 • 1,226 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Virus treatment questioned after gene therapy death

1999 • 578 citations

Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.

1994 • 438 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector.

1995 • 277 citations

Interleukin-12 Therapy of Cutaneous T-Cell Lymphoma Induces Lesion Regression and Cytotoxic T-Cell Responses

1999 • 272 citations

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.

1996 • 248 citations

Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts.

1995 • 206 citations

The Toxicology of Interleukin-12: A Review

1999 • 204 citations

Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

1996 • 193 citations

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

1999 • 192 citations

Amount of interleukin 12 available at the tumor site is critical for tumor regression.

1996 • 177 citations

Antitumor Efficacy of Adenocarcinoma Cells Engineered to Produce Interleukin 12 (IL-12) or Other Cytokines Compared With Exogenous IL-12

1997 • 174 citations

Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

1995 • 172 citations

Cytokine and chemokine expression in tumors of mice receiving systemic therapy with IL-12.

1996 • 166 citations

Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12

1999 • 151 citations

A New Cationic Liposome DNA Complex Enhances the Efficiency of Arterial Gene Transfer In Vivo

1996 • 122 citations

Cytokine Gene Therapy of Cancer Using Gene Gun Technology: Superior Antitumor Activity of Interleukin-12

1997 • 118 citations

A gene therapy for cancer using intramuscular injection of plasmid DNA encoding interferon α

1999 • 116 citations

Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer.

1997 • 112 citations

Intratumoral coinjection of adenoviral vectors expressing IL-2 and IL-12 results in enhanced frequency of regression of injected and untreated distal tumors

1998 • 110 citations

Particle-Mediated Gene Transfer of Granulocyte-Macrophage Colony-Stimulating Factor cDNA to Tumor Cells: Implications for a Clinically Relevant Tumor Vaccine

1996 • 90 citations

Costimulation Enhances the Active Immunotherapy Effect of Recombinant Anticancer Vaccines

1996 • 84 citations

Gene Gun-Mediated IL-12 Gene Therapy Induces Antitumor Effects in the Absence of Toxicity: A Direct Comparison With Systemic IL-12 Protein Therapy

1999 • 81 citations

Role of NK and T cells in IL-12-induced anti-tumor response against hepatic colon carcinoma

1999 • 79 citations

Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1β converting enzyme cDNA

1999 • 76 citations

Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma

1998 • 71 citations

Antitumor effects of interleukin-12 in pre-clinical and early clinical studies (Review).

1999 • 68 citations

Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism

2000 • 67 citations

Intratumoral delivery of IL-12 gene by polyvinyl polymeric vector system to murine renal and colon carcinoma results in potent antitumor immunity

1999 • 66 citations

Long-Lasting Anti-Metastatic Efficiency of Interleukin 12-Encoding Plasmid DNA

1999 • 62 citations

Canarypox Virus-Mediated Interleukin 12 Gene Transfer into Murine Mammary Adenocarcinoma Induces Tumor Suppression and Long-Term Antitumoral Immunity

1998 • 59 citations

Administration of Recombinant Interleukin-12 to Mice Suppresses Hematopoiesis in the Bone Marrow but Enhances Hematopoiesis in the Spleen

1995 • 53 citations

Cancer Trial of Interleukin-12 Halted

1995 • 51 citations

High Frequency of Specific CD8+ T Cells in the Tumor and Blood Is Associated with Efficient Local IL-12 Gene Therapy of Cancer

1999 • 47 citations

Intratracheal Administration of Interleukin 12 Plasmid-Cationic Lipid Complexes Inhibits Murine Lung Metastases

1999 • 47 citations

Intradermal Delivery of IL-12 Naked DNA Induces Systemic NK Cell Activation and Th1 Response In Vivo That Is Independent of Endogenous IL-12 Production

1999 • 43 citations

Murine Models of Cancer Cytokine Gene Therapy Using Interleukin‐12a

1996 • 42 citations

Immunotherapy of established tumors in mice by intratumoral injection of interleukin-2 plasmid DNA: induction of CD8+ T-cell immunity.

1998 • 41 citations

Introduction of murine Il-4 gene into B16(F10) melanoma tumors by direct gene transfer with DNA-liposome complexes

1995 • 27 citations

Interleukin-12 Gene Transfer Results in CD8-Dependent Regression of Murine CT26 Liver Tumors

1999 • 24 citations

Tissue Distribution of the Cytofectin Component of a Plasmid–DNA/Cationic Lipid Complex Following Intravenous Administration in Mice

1997 • 23 citations

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine Interleukin 12

1998 • 19 citations

Cancer immunotherapy by direct in vivo transfer of immunomodulatory genes

1998 • 15 citations

Accumulation of IL-12-activated antitumor effector cells into lymph nodes of tumor-bearing mice

1998 • 5 citations

Neural toxicity of retroviruses

1996 • 5 citations