Characterisation of patients with primary biliary cirrhosis responding to long term ursodeoxycholic acid treatment

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Microdroplet Assay of Human Serum Cytotoxins

1964 • 2,088 citations

Prognosis in primary biliary cirrhosis: Model for decision making

1989 • 814 citations

Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)

1978 • 731 citations

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

1997 • 624 citations

HL‐A Antigens and Disease Statistical and Genetical Considerations

1974 • 524 citations

Ursodeoxycholic acid in the treatment of primary biliary cirrhosis

1994 • 474 citations

The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

1994 • 431 citations

Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis

1985 • 407 citations

Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial

1989 • 359 citations

A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis*1

1995 • 275 citations

Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis.

1994 • 242 citations

Measuring the strength of associations between HLA antigens and diseases

1981 • 239 citations

Autoimmune cholangiopathy: Part of the spectrum of autoimmune chronic active hepatitis

1993 • 219 citations

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

1994 • 213 citations

Molecular aspects of membrane stabilization by ursodeoxycholate

1993 • 212 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1994 • 211 citations

Autoimmune cholangitis: A variant of primary biliary cirrhosis

1995 • 178 citations

Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei

1997 • 177 citations

Tauroursodeoxycholic acid activates protein kinase C in isolated rat hepatocytes

1996 • 141 citations

Rapid HLA‐DRB1 genotyping by nested PCR amplification

1992 • 139 citations

A randomized, double-blind, placebo-controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

1995 • 113 citations

Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages.

1996 • 112 citations

Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis? Outcomes of ursodeoxycholic acid therapy and liver transplantation

1997 • 104 citations

Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis?

1996 • 93 citations

Clinical significance of serum bilirubin levels under ursodeoxycholic acid therapy in patients with primary biliary cirrhosis

1999 • 83 citations

Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria

1994 • 77 citations

Characterisation of patients with a complete biochemical response to ursodeoxycholic acid.

1995 • 75 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria*1

1994 • 71 citations

Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis

1994 • 48 citations

p53 expression in patients with cirrhosis with and without hepatocellular carcinoma

1995 • 45 citations

Ursodeoxycholate stabilizes phospholipid-rich membranes and mimics the effect of cholesterol: investigations on large unilamellar vesicles

1997 • 42 citations

Antimitochondrial antibody profiles in primary biliary cirrhosis distinguish at early stages between a benign and a progressive course: a prospective study on 200 patients followed for 10 years

1997 • 41 citations

High performance liquid chromatographic determination of free and conjugated bile acids in serum, liver biopsies, bile, gastric juice and feces by fluorescence labeling

1993 • 35 citations

Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis.

1998 • 32 citations

Natural course of primary biliary cirrhosis. I. A morphological, clinical and serological analysis of 103 cases

1982 • 31 citations

Is the Mayo model for predicting survival useful after the introduction of ursodeoxycholic acid treatment for primary biliary cirrhosis

1996 • 19 citations