Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria

Ciba foundation symposium

1964 • 2,217 citations

[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios

1967 • 1,785 citations

Statistical Methods in Medical Research.

1988 • 1,431 citations

A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Biliary Cirrhosis

1991 • 727 citations

IS URSODEOXYCHOLIC ACID AN EFFECTIVE TREATMENT FOR PRIMARY BILIARY CIRRHOSIS?

1987 • 532 citations

Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial

1992 • 449 citations

Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial

1989 • 359 citations

Influence of Hydroxylation and Conjugation of Bile Salts on Their Membrane-Damaging Properties-Studies on Isolated Hepatocytes and Lipid Membrane Vesicles

1984 • 290 citations

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.

1993 • 251 citations

Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes

1990 • 251 citations

Effect of sodium taurolithocholate on bile flow and bile acid excretion

1968 • 247 citations

Riboflavin and rat hepatic cell structure and function. Mitochondrial oxidative metabolism in deficiency states.

1979 • 238 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1994 • 211 citations

Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts:In vitro studies in rat hepatocytes and human erythrocytes

1991 • 208 citations

Hepatic injury induced by bile salts: Correlation between biochemical and morphological events

1990 • 207 citations

A rapid method for the quantitative extraction of bile acids and their conjugates from serum using commercially available reverse-phase octadecylsilane bonded silica cartridges

1982 • 198 citations

Ursodeoxycholic acid for primary sclerosing cholangitis

1990 • 165 citations

Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis

1990 • 140 citations

Effects of ursodeoxycholic acid treatment on nutrition and liver function in patients with cystic fibrosis and longstanding cholestasis.

1990 • 128 citations

Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis

1990 • 118 citations

Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover rates in human serum using 13C-labeled bile acids.

1984 • 116 citations

Hepatic Alterations During Total Parenteral Nutrition in Patients with Inflammatory Bowel pisease: A Possible Consequence of Lithocholate Toxicity

1982 • 106 citations

Effects of different bile salts upon the composition and morphology of a liver plasma membrane preparation. Deoxycholate is more membrane damaging than cholate and its conjugates

1977 • 94 citations

Scanning Electron Microscopy of the Rat Liver

1975 • 90 citations

Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis

1989 • 89 citations

Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis

1992 • 85 citations

Effect of chenodeoxycholic and ursodeoxycholic acids on isolated adult human hepatocytes

1984 • 81 citations

Ursodeoxycholic acid limits liver histologic alterations and portal hypertension induced by bile duct ligation in the rat

1992 • 64 citations

The respective roles of membrane cholesterol and of sodium potassium adenosine triphosphatase in the pathogenesis of lithocholate-induced cholestasis.

1980 • 61 citations

Mechanisms of impaired hepatic fatty acid metabolism in rats with long-term bile duct ligation

1994 • 56 citations

Ursodeoxycholic acid in chronic liver disease.

1991 • 52 citations

Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: Impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte

1992 • 50 citations

Nature of tissue-bound lithocholic acid and its implications in the role of bile acids in carcinogenesis.

1981 • 48 citations

Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic treatment.

1989 • 47 citations

The regulation of cell metabolism

1968 • 43 citations

Isolation of tissue-bound lithocholic acid from livers of rats treated with methylazoxymethanol

1981 • 16 citations

The order of hepatic cytotoxicity of bile salts in vitro does not agree with that examined in vivo in rats

1990 • 14 citations