Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

[43] Malondialdehyde determination as index of lipid Peroxidation

1990 • 4,022 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Reactive oxygen species in living systems: Source, biochemistry, and role in human disease

1991 • 1,827 citations

A Multicenter, Controlled Trial of Ursodiol for the Treatment of Primary Biliary Cirrhosis

1991 • 727 citations

Monocytes and Macrophages

1988 • 711 citations

IS URSODEOXYCHOLIC ACID AN EFFECTIVE TREATMENT FOR PRIMARY BILIARY CIRRHOSIS?

1987 • 532 citations

Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions.

1989 • 523 citations

Ursodiol for the Long-Term Treatment of Primary Biliary Cirrhosis

1994 • 477 citations

Ursodeoxycholic acid in the treatment of primary biliary cirrhosis

1994 • 474 citations

The canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis

1994 • 431 citations

Liver cell necrosis: Cellular mechanisms and clinical implications

1995 • 393 citations

Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial

1989 • 359 citations

Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium.

1993 • 251 citations

Immunomodulatory Effects of Ursodeoxycholic Acid on Immune Responses

1992 • 235 citations

Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection.

1995 • 231 citations

Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts

1991 • 221 citations

Molecular aspects of membrane stabilization by ursodeoxycholate

1993 • 212 citations

Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria

1994 • 211 citations

Hepatic injury induced by bile salts: Correlation between biochemical and morphological events

1990 • 207 citations

Pharmacology of Ursodeoxycholic Acid, an Enterohepatic Drug

1994 • 201 citations

Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide‐mediated killing

1993 • 196 citations

Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes

1993 • 192 citations

Measuring free radical reactions in vivo

1993 • 168 citations

Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties

1994 • 147 citations

Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid

1994 • 131 citations

Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration

1991 • 122 citations

Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis

1990 • 118 citations

Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts

1994 • 110 citations

Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children

1995 • 81 citations

Ursodeoxycholate protects oxidative mitochondrial metabolism from bile acid toxicity: Dose-response study in isolated rat liver mitochondria

1994 • 77 citations

The immunosuppressive effect of ursodeoxycholic acid: A comparativein vitro study on human peripheral blood mononuclear cells

1993 • 75 citations

A multi-center double-blind controlled trial of ursodeoxycholic acid for primary biliary cirrhosis

1990 • 68 citations

Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids

1991 • 52 citations

Effects of ursodeoxycholic acid after 4 to 12 years of therapy in early and late stages of primary biliary cirrhosis

1994 • 48 citations

Bile acid glycine and taurine conjugates in serum of patients with primary biliary cirrhosis: effect of ursodeoxycholic treatment.

1989 • 47 citations

Relationship of bile salt stimulation of colonic epithelial phospholipid turnover and proliferative activity: Role of activation of protein kinase C

1987 • 28 citations

Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids,

1991 • 23 citations

Ursodeoxycholate-induced hypercholeresis in cirrhotic rats: Further evidence for cholehepatic shunting

1994 • 14 citations

Ursodeoxycholic acid induces significant changes of plasma bile acids in primary biliary cirrhosis

1989 • 4 citations

Mechanism of bile acid-induced HCO3−-rich hypercholeresis

1992 • 4 citations

Ursodeoxycholate decreases mitochondrial toxicity and membrane incorporation of lipophilic bile acids

1993 • 2 citations