Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

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Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

2004 • 2,779 citations

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

2001 • 2,539 citations

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

2007 • 1,790 citations

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

2004 • 1,508 citations

FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

2007 • 1,390 citations

Rapid Disuse Atrophy of Diaphragm Fibers in Mechanically Ventilated Humans

2008 • 1,387 citations

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PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

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Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

2004 • 549 citations

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Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

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Ventilator-induced Diaphragmatic Dysfunction

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Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts

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The Many Forks in FOXO's Road

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Is Weaning Failure Caused by Low-Frequency Fatigue of the Diaphragm?

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Mechanical Ventilation–induced Diaphragmatic Atrophy Is Associated with Oxidative Injury and Increased Proteolytic Activity

2002 • 338 citations

Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes

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Mechanical ventilation results in progressive contractile dysfunction in the diaphragm

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Altered diaphragm contractile properties with controlled mechanical ventilation

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Effects of mechanical ventilation on diaphragmatic contractile properties in rats.

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Hsp70 overexpression inhibits NF‐κB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy

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p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

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Lysosomal proteolysis in skeletal muscle

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Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

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Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the intensive care unit

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Effects of prolonged controlled mechanical ventilation on diaphragmatic function in healthy adult baboons

1997 • 195 citations

Mechanical ventilation-induced oxidative stress in the diaphragm

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Caspase-3 Regulation of Diaphragm Myonuclear Domain during Mechanical Ventilation–induced Atrophy

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Blood levels of cytokines in brain-dead patients: Relationship with circulating hormones and acute-phase reactants

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Mechanical Ventilation Depresses Protein Synthesis in the Rat Diaphragm

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Antioxidant administration attenuates mechanical ventilation‐induced rat diaphragm muscle atrophy independent of protein kinase B (PKB–Akt) signalling

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14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin

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Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm

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The Role of Cytokines during the Pathogenesis of Ventilator-Associated and Ventilator-Induced Lung Injury

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Downregulation of Akt/mammalian target of rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia

2010 • 115 citations

Leupeptin Inhibits Ventilator-induced Diaphragm Dysfunction in Rats

2007 • 110 citations

Protein Carbonyl Formation in the Diaphragm

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Adenosine transport in cultured human umbilical vein endothelial cells is reduced in diabetes

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Effects of controlled mechanical ventilation on respiratory muscle contractile properties in rabbits

2003 • 106 citations

Controlled Mechanical Ventilation Leads to Remodeling of the Rat Diaphragm

2002 • 106 citations

Detrimental effects of short-term mechanical ventilation on diaphragm function and IGF-I mRNA in rats

2003 • 103 citations

Delivery of proteins and organelles to the vacuole from the cytoplasm

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Abnormalities of diaphragmatic muscle in neonates with ventilated lungs

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Mechanical ventilation promotes redox status alterations in the diaphragm

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FoxO1 induces apoptosis in skeletal myotubes in a DNA-binding-dependent manner

2009 • 88 citations

Effects of prolonged mechanical ventilation on respiratory muscle ultrastructure and mitochondrial respiration in rabbits

2003 • 84 citations

Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation

2009 • 81 citations

AWAKE TRACHEOBRONCHIAL DILATATION WITHOUT THE USE OF RIGID BRONCHOSCOPY

2005 • 76 citations

Regulation of Proliferation of Skeletal Muscle Precursor Cells By NADPH Oxidase

2007 • 67 citations

Effects of short vs. prolonged mechanical ventilation on antioxidant systems in piglet diaphragm

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The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

2010 • 58 citations

Early Changes in Rat Diaphragm Biology with Mechanical Ventilation

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The Many Forks in FOXO's Road

2003 • 38 citations

Changes in diaphragm structure following prolonged mechanical ventilation in piglets

2004 • 37 citations

Early effects of mechanical ventilation on isotonic contractile properties and MAF-box gene expression in the diaphragm

2005 • 37 citations