The cathepsin L gene is a direct target of FOXO1 in skeletal muscle

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

2004 • 2,779 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

2004 • 1,836 citations

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

2007 • 1,790 citations

[41] Cathepsin B, cathepsin H, and cathepsin L

1981 • 1,678 citations

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

2004 • 1,508 citations

FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

2007 • 1,390 citations

FoxOs at the Crossroads of Cellular Metabolism, Differentiation, and Transformation

2004 • 1,294 citations

Unified nomenclature for the winged helix/forkhead transcription factors

2000 • 1,136 citations

Calcium Ion in Skeletal Muscle: Its Crucial Role for Muscle Function, Plasticity, and Disease

2000 • 956 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 608 citations

FoxO proteins in insulin action and metabolism

2005 • 589 citations

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

2006 • 563 citations

Skeletal Muscle FOXO1 (FKHR) Transgenic Mice Have Less Skeletal Muscle Mass, Down-regulated Type I (Slow Twitch/Red Muscle) Fiber Genes, and Impaired Glycemic Control

2004 • 549 citations

Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues

2000 • 483 citations

Molecular mechanisms modulating muscle mass

2003 • 428 citations

Cloning and Characterization of Three Human Forkhead Genes That Comprise an FKHR-like Gene Subfamily

1998 • 350 citations

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation

2003 • 323 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR

2000 • 273 citations

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

2007 • 271 citations

Metabolism at a glance

1993 • 267 citations

FOXO Forkhead Transcription Factors Induce G2-M Checkpoint in Response to Oxidative Stress

2002 • 265 citations

Lysosomal proteolysis in skeletal muscle

2005 • 238 citations

Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors

2003 • 204 citations

Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice

2003 • 204 citations

FOXO-binding partners: it takes two to tango

2008 • 203 citations

The FoxO transcription factors and metabolic regulation

2007 • 169 citations

Quantitative analysis of the human alpha-skeletal actin gene in transgenic mice.

1993 • 169 citations

Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting

2001 • 157 citations

FoxO1 Stimulates Fatty Acid Uptake and Oxidation in Muscle Cells through CD36-dependent and -independent Mechanisms

2005 • 147 citations

Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression

2006 • 133 citations

A forkhead transcription factor FKHR up‐regulates lipoprotein lipase expression in skeletal muscle

2003 • 129 citations

Activating Transcription Factor 3 Constitutes a Negative Feedback Mechanism That Attenuates Saturated Fatty Acid/Toll-Like Receptor 4 Signaling and Macrophage Activation in Obese Adipose Tissue

2009 • 110 citations

Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting

2001 • 109 citations

Differential Regulation of Endogenous Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression by the Forkhead Transcription Factor FKHR in H4IIE-Hepatoma Cells

2001 • 104 citations

FOXO Transcription Factors in the Regulatory Networks of Longevity

2007 • 96 citations

Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor

2008 • 76 citations

Cathepsin L Gene Expression and Promoter Activation in Rodent Granulosa Cells

2003 • 52 citations

Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity

2002 • 40 citations

Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity

2001 • 30 citations

Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.

1991 • 28 citations

Cloning and characterization of human cathepsin L promoter

2001 • 22 citations

A GC-Box Within the Proximal Promoter Region of the Rat Cathepsin L Gene Activates Transcription in Sertoli Cells of Sexually Mature Rats1

2003 • 13 citations